4-Fluorobenzamidine hydrochloride Chemical Properties

Melting point:

209.0 to 213.0 °C

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

HS Code 

2916310090

4-Fluorobenzamidine hydrochloride Usage And Synthesis

Uses

4-Fluorobenzamidine hydrochloride is used as pharmaceutical intermediate.

Synthesis

GENERAL METHOD: Ethyl sialic acid hydrochloride (10 mmol) was dissolved in ethanol (10 mL) and transferred to a round-bottomed flask equipped with a magnetic stirrer. After sealing the flask with a rubber stopper, a methanol solution of ammonia (10 mL) was slowly added to the reaction system via a syringe. The reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting crude product was purified by rapid column chromatography on silica gel (eluent: ethyl acetate/methanol, 4:1, v/v) to afford 4-fluorobenzenemethanimidamide hydrochloride (1j) as a white solid in 87% yield (1.52 g, 8.7 mmol).

References

[1] Tetrahedron, 2014, vol. 70, # 8, p. 1635 - 1645

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