2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Chemical Properties

storage temp. 

Store at -20°C

solubility 

Chloroform: slightly soluble; Methanol: slightly soluble

form 

A solid

2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Usage And Synthesis

Description

Ketoconazole-d₃ is intended for use as an internal standard for the quantification of ketoconazole by GC- or LC-MS. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC₅₀s = 0.031-8 μg/ml).¹ It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC₅₀ = 0.54 μM). Formulations containing ketoconazole have been used in the treatment of fungal infections.

Uses

Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.

References

1. Dilmaghanian, S., Gerber, J.G., Filler, D.G., et al. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates Chirality 16(2),79-85(2004).

2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone(1217766-70-5)Related Product Information

• Ketoconazole Impurity 3
• cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
• Ketoconazole Impurity 1
• KetoconazoleN-Oxide
• Ketoconazole Impurity 4
• 2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL METHYL)-1,3-DIOXOLANE-4-METHANOL
• KETOCONAZOLE INTERMEDIATE
• rac-trans-Ketoconazole
• Ketoconazole
• Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity)
• Ketoconazole Impurity 6
• Tosyl chloride
• cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
• 4-(1-Acetylpiperazin-4-yl)phenol
• 1,3-Difluorobenzene
• 2,3-Dehydro Ketoconazole
• 2',4'-Dichloroacetophenone
• Ketoconazole-13C-d3