Basic information Safety Supplier Related

4-(1-Acetylpiperazin-4-yl)phenol

Basic information Safety Supplier Related

4-(1-Acetylpiperazin-4-yl)phenol Basic information

Product Name:
4-(1-Acetylpiperazin-4-yl)phenol
Synonyms:
  • TIMTEC-BB SBB003353
  • N-ACETYL-4-HYDROXYPHENYL PIPERAZINE
  • N-ACETYL-4-(4-HYDROXYPHENYL)PIPERAZINE
  • 1-Acetyl-4-(4-hydroxyphenyl)piperazine, 98+%
  • 1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanon
  • Piperazine, 1-acetyl-4-(4-hydroxyphenyl)-
  • 1-Acetyl-4-(4-Hydroxy-Phenyl)PiperazineKetoconazole
  • 4-(4-Acetylpiperazino)phenol
CAS:
67914-60-7
MF:
C12H16N2O2
MW:
220.27
EINECS:
267-744-8
Product Categories:
  • Piperaizine
  • Miscellaneous
  • Chemical Amines
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Chemical intermediate for Ketoconazole
  • Piperidines, Piperidones, Piperazines
  • Pharmaceuticals
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
Mol File:
67914-60-7.mol
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4-(1-Acetylpiperazin-4-yl)phenol Chemical Properties

Melting point:
180-185 °C (lit.)
Boiling point:
361.21°C (rough estimate)
Density 
1.1115 (rough estimate)
vapor pressure 
0Pa at 20℃
refractive index 
1.6000 (estimate)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
12.18±0.30(Predicted)
color 
White to slightly pink or beige
Water Solubility 
4.3 g/L (20 ºC)
BRN 
795777
InChIKey
AGVNLFCRZULMKK-UHFFFAOYSA-N
LogP
0.3
CAS DataBase Reference
67914-60-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
HS Code 
29214910

MSDS

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4-(1-Acetylpiperazin-4-yl)phenol Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs.

General Description

1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP), a piperazine derivative, is a structural analog of acetaminophen. Its multi-step preparation using bis-(2-chloroethyl)amine hydrochloride and p-aminophenol as starting materials has been reported.2

Flammability and Explosibility

Not classified

4-(1-Acetylpiperazin-4-yl)phenol Preparation Products And Raw materials

Preparation Products

Raw materials

4-(1-Acetylpiperazin-4-yl)phenolSupplier

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