4-Chlorobenzyl cyanide Chemical Properties

Melting point:

25-28 °C(lit.)

Boiling point:

265-267 °C(lit.)

Density 

1.19 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.543

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.3g/l

form 

Liquid After Melting

color 

Clear colorless to yellow

BRN 

971171

Exposure limits

NIOSH: IDLH 25 mg/m3

InChIKey

IVYMIRMKXZAHRV-UHFFFAOYSA-N

CAS DataBase Reference

140-53-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneacetonitrile, 4-chloro-(140-53-4)

EPA Substance Registry System

Benzeneacetonitrile, 4-chloro- (140-53-4)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

23/24/25-36/37/38

Safety Statements 

26-36/37/39-45-28B

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

AL8250000

Hazard Note 

Irritant/Toxic

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29269095

MSDS

• Language:English Provider:4-Chlorobenzyl cyanide
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4-Chlorobenzyl cyanide Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid after melting. Soluble in acetone and ethanol.

Uses

4-Chlorobenzyl cyanide is an intermediate for the preparation of 3-methyl-2-(4-chlorophenyl)butyric acid, which can be used to prepare pyrethroid insecticides such as fenvalerate and deltamethrin, and can be used in medicine Industrial preparation of pyrimethamine.

Preparation

4-Chlorobenzyl cyanide is obtained by the reaction of 4-Chlorobenzyl chloride with sodium cyanide. Add 4-Chlorobenzyl chloride and Benzyldodecyldimethylammonium bromide into the reaction pot, heat to 100°C, slowly add sodium cyanide aqueous solution, and react at 100-104°C for 5h (add sodium cyanide for 3h, keep warm for 2h). Then add water to dissolve sodium chloride, and separate the water layer to obtain the crude benzyl chloride cyanide, which is distilled under reduced pressure to collect 160 (2.66kPa) fractions to obtain the finished product of 4-Chlorobenzyl cyanide. The yield is above 81%.

Definition

ChEBI: 4-Chlorobenzyl cyanide is a nitrile that is acetonitrile in which one of the hydrogens has been replaced by a p-chlorophenyl group. It is a member of monochlorobenzenes and a nitrile. It derives from an acetonitrile.

4-Chlorobenzyl cyanide(140-53-4)Related Product Information

• Pralmorelin
• p-Nitrophenylacetonitrile
• 5-Chlorovaleric acid
• DL-α-Tocopherol
• 4-Methoxybenzyl cyanide
• Copper(I) Cyanide
• Diphenolic acid
• Trichloroacetonitrile
• 4-Chlorostyrene
• 4-CHLOROPHENETOLE
• 4-Chlorophenoxyacetic acid
• 4-Chlorophenylacetic acid
• 4'-Chloroacetophenone
• 2-(2-Chlorophenyl)acetonitrile
• 3-Chlorobenzyl Cyanide m-Chlorobenzyl Cyanide,M-CHLOROBENZYL CYANIDE,3-CHLOROBENZYL CYANIDE
• Glycolonitrile
• 1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile
• 3,4-Dichlorophenylacetonitrile