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TYRPHOSTIN AG 126

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TYRPHOSTIN AG 126 Basic information

Product Name:
TYRPHOSTIN AG 126
Synonyms:
  • RARECHEM AL BX 0673
  • TYRPHOSTIN A10
  • TYRPHOSTIN AG 126
  • ag127
  • AG 126
  • ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE
  • [3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE
  • Tyrphostin 126
CAS:
118409-62-4
MF:
C10H5N3O3
MW:
215.16
Product Categories:
  • API
Mol File:
118409-62-4.mol
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TYRPHOSTIN AG 126 Chemical Properties

storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
Yellow solid
color 
Light yellow to yellow
Sensitive 
Light Sensitive
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
26-36-45
WGK Germany 
3
HazardClass 
6.1
HS Code 
2926907090

MSDS

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TYRPHOSTIN AG 126 Usage And Synthesis

Definition

ChEBI: 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.

Biological Activity

ag-126 is an erk1 and erk2 inhibitor.extracellular signal-regulated kinases (erks) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the erk pathway.

in vitro

previous study found that r ag126 ould potently inhibit the pcw-evoked release and this effect was rather selective with respect to the stimulus. ag126 was found to be less potent in attenuating lps-triggered release. moreover, it was found that ag126 was able to prevent the pcw-inducible erk phosphorylation, which could relate to the ag126-mediated inhibition of pcw-evoked cytokine release [1].

in vivo

ag126 was tested in a model of pcw-induced meningitis, in which rats underwent intracisternal injection of pcw with and without ag126 pretreatment. pcw injection led to a dramatic leukocyte influx into the csf. ag126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. in addition, ag126 treatment showed beneficial effects on other parameters, such as intracranial pressure. furthermore, ag126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial pao2, paco2 as well as ph [1].

IC 50

inhibits the phosphorylation of erk1 and erk2 at 25-50 μm

References

[1] hanisch, u. k.,prinz, m.,angstwurm, k., et al. the protein tyrosine kinase inhibitor ag126 prevents the massive microglial cytokine induction by pneumococcal cell walls. european journal of immunology 31, 2104-2115 (2001).

TYRPHOSTIN AG 126Supplier

Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66099280 17798518460
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cfzhang@aikonchem.com
TOKYO CHEMICAL INDUSTRY CO., LTD.
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