8-HYDROXYOCTANOIC ACID Chemical Properties

Melting point:

59-63 °C

Boiling point:

130°C/1mm

Density 

1.0227 (rough estimate)

refractive index 

1.4370 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

pka

4.77±0.10(Predicted)

form 

crystalline powder

color 

White

BRN 

1237092

LogP

0.900 (est)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

HS Code 

2918199890

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

8-HYDROXYOCTANOIC ACID Usage And Synthesis

Chemical Properties

light yellow powder

Uses

8-Hydroxyoctanoic Acid is an intermediate in the synthesis of mono-carboxy-isooctyl-phthalate (M525590). 8-Hydroxyoctanoic Acid is also used as a reagent in the synthesis of histone deacetylases (HDAC) inhibitors with an N-formyl hydroxylamine head group which are promising targets for cancer chemotherapy.

Definition

ChEBI: An omega-hydroxy fatty acid that is caprylic acid in which one of the hydrogens of the terminal methyl group is replaced by a hydroxy group.

General Description

8-Hydroxyoctanoic acid is one of the constituents of ‘‘Royal jelly′′ acid found in herbhoneys and genuine honeys.

Synthesis

GENERAL PROCEDURE: All catalytic activity testing experiments were carried out in Schlenk tubes (50 mL) equipped with a condenser. 8-Hydroxycaprylic acid (HCA) was prepared by HDO oxidation reaction in alkaline aqueous medium using H2O2 as oxidant. The typical reaction procedure was as follows: first, the aliphatic diol (0.5 mmol) was weighed and dispersed with catalyst (25 mg) in deionized water (3.5 mL) in a Schlenk tube. Subsequently, 30% H2O2 (0.75 mL) and 0.5 M NaOH (0.75 mL) were added to the above mixture. The Schlenk tubes were placed in an oil bath preheated to 353 K and reacted for different time intervals under continuous magnetic stirring (500 rpm). After completion of the reaction, a portion of the reaction solution was taken and diluted 20-fold with 10 mM aqueous H2SO4 and the catalyst was removed by passing it through a 0.20 μm filter (Milex-LG). The resulting filtrate was analyzed by high performance liquid chromatography (HPLC, WATERS 600) on an Aminex HPX-87H column (Bio-Rad Laboratories, Inc.) with a refractive index detector. An aqueous solution of 10 mM H2SO4 was used as the eluent at a flow rate of 0.5 mL/min, and the column temperature was maintained at 323 K. The conversion and yield were determined by the calibration curve method for commercial products.

References

[1] Catalysis Today, 2016, vol. 265, p. 231 - 239

8-HYDROXYOCTANOIC ACID(764-89-6)Related Product Information

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• QUASSIN
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• LOGANIC ACID
• SHANZHISIDE METHYL ESTER
• Madecassoside
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• Suberic acid
• 3-HYDROXYOCTANOIC ACID,(+/-)-3-HYDROXYOCTANOIC ACID
• 3α-Methyl-4β-hydroxyoctanoic acid lactone
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• 2-HYDROXYOCTANOIC ACID,(+/-)-2-HYDROXYOCTANOIC ACID,DL-2-HYDROXYOCTANOIC ACID