(S)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties

Melting point:

60-62 °C

Boiling point:

321 °C

Density 

1.118

Flash point:

148 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

14.36±0.10(Predicted)

form 

solid

color 

White

Water Solubility 

Slightly soluble in water.

Sensitive 

Light Sensitive

InChI

InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m0/s1

InChIKey

FJYBLMJHXRWDAQ-QMMMGPOBSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCO[C@H](CO)C1

CAS DataBase Reference

135065-76-8

Safety Information

HS Code 

2933998090

(S)-N-Boc-2-Hydroxymethylmorpholine Usage And Synthesis

Uses

(S)-N-Boc-2-hydroxymethylmorpholine is used as a pharmaceutical intermediate.

Synthesis

Under stirring conditions, (S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate (5.27 g, 17.2 mmol) was dissolved in 200 mL of ethanol, followed by the addition of 0.527 g of palladium/activated carbon catalyst and two drops of 1N hydrochloric acid. The reaction system was replaced three times with hydrogen and then reacted overnight at 70 °C under hydrogen atmosphere, and the reaction progress was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with 100 mL of saturated sodium bicarbonate solution and extracted with ethyl acetate (200 mL × 4). The organic phases were combined, washed sequentially with 100 mL of water and 100 mL of saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford (S)-N-Boc-2-hydroxymethylmorpholine (3.646 g, 97.7% yield) as colorless to light yellow liquid. Mass spectrum (ESI) m/z: 240.3 [M + 23]. 1H NMR (CDCl3, 400 MHz) δ 3.92-3.88 (m, 3H), 3.7-3.64 (m, 1H), 3.60-3.48 (m, 3H), 2.936 (m, 1H), 2.75 (m, 1H), 2.06 (m, 1H), 1.46 (s , 9H).

References

[1] Patent: EP2189451, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: US2010/210640, 2010, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/6715, 2007, A1. Location in patent: Page/Page column 34; 35
[4] Patent: WO2007/6714, 2007, A1. Location in patent: Page/Page column 122
[5] Patent: WO2006/105262, 2006, A1. Location in patent: Page/Page column 74; 75

(S)-N-Boc-2-Hydroxymethylmorpholine(135065-76-8)Related Product Information

• BUTYL OLEATE
• Butyl acetate
• Cyhalofop-butyl
• Moroxydine hydrochloride
• tert-Butyl peroxyacetate
• tert-Butyl acetate
• Buprofezin
• Tridemorph
• tert-Butanol
• Dimethomorph
• Moroxydine
• Tris(trimethylsilyl)phosphate
• (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE
• (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
• (S)-N-Boc-2-aminomethylmorpholine
• (S)-1-Boc-2-(Hydroxymethyl)piperazine
• 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate