5-[(2-Hydroxyethyl)amino]-o-cresol Chemical Properties

Melting point:

90-92℃

Boiling point:

366.0±32.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

vapor pressure 

0.004Pa at 20℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

10.28±0.10(Predicted)

color 

Light Beige

Water Solubility 

37g/L at 20℃

LogP

0.772 at 23℃

CAS DataBase Reference

55302-96-0(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

RTECS 

SL5078600

HS Code 

29225090

5-[(2-Hydroxyethyl)amino]-o-cresol Usage And Synthesis

Chemical Properties

Light brown powder

Flammability and Explosibility

Not classified

Synthesis

In a 250 mL four-necked flask fitted with a thermometer and stirrer, 12.3 g (0.1 mol) of 5-amino-2-methylphenol was dissolved in 80 mL of diethylene glycol dimethyl ether and heated to 150 °C. Under slow stirring in a cold trap, 4.4 g (0.1 mol) of ethylene oxide was dissolved in 10 mL of diethylene glycol dimethyl ether and 0.3 g of NaY molecular sieve catalyst was added to a four-necked flask, followed by dropwise addition of the mixture. After the dropwise addition process lasted for 0.5 hr, the reaction was continued for 3 hr. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure, dried and the residue was cooled to give 16.6 g of 5-(2-hydroxyethyl)amino-o-cresol crude product. The crude product was dissolved in 100 mL of methanol-water mixed solvent and recrystallized to give 15.7 g of refined 5-(2-hydroxyethyl)amino-o-cresol in 94.1% yield and 99.52% purity.

References

[1] Patent: CN106588678, 2017, A. Location in patent: Paragraph 0025; 0026; 0028; 0030; 0031; 0032; 0034

5-[(2-Hydroxyethyl)amino]-o-cresol(55302-96-0)Related Product Information

• ALTRENOGEST
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