Basic information Safety Supplier Related

Amsacrine hydrochloride

Basic information Safety Supplier Related

Amsacrine hydrochloride Basic information

Product Name:
Amsacrine hydrochloride
Synonyms:
  • m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride
  • Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride
  • Methanesulfon-m-anisidide 4'-(9-acridinylamino)-
  • Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride
  • 4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE
  • M-AMSA HYDROCHLORIDE
  • M-AMSA, HCL
  • Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride
CAS:
54301-15-4
MF:
C21H20ClN3O3S
MW:
429.92
EINECS:
637-255-8
Mol File:
54301-15-4.mol
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Amsacrine hydrochloride Chemical Properties

Melting point:
197-199 °C(lit.)
storage temp. 
Refrigerator
solubility 
DMSO: 10 mg/mL with heat and sonication
form 
powder
color 
red to brown
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Safety Information

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
PB1081000
HS Code 
2933.99.8290
HazardClass 
6.1(b)
PackingGroup 
III
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Amsacrine hydrochloride Usage And Synthesis

Uses

Amsacrine hydrochloride has been used:

  • as a topoisomerase poison in bacteriophage T4 topoisomerase assay
  • as a topoisomerase inhibitor in Drosophila cell line, Kc167
  • as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
  • as a topoisomerase II poison in dose-response assays in C elegans

Biological Activity

amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].

Biochem/physiol Actions

Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.

References

[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.

Amsacrine hydrochloride Preparation Products And Raw materials

Preparation Products

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