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Rafoxanide

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Rafoxanide Basic information

Product Name:
Rafoxanide
Synonyms:
  • 3’-chloro-4’-(p-chlorophenoxy)-3,5-diiodo-salicylanilid
  • 3’-chloro-4’-(p-chlorophenoxy)-3,5-diiodosalicylanilide
  • bovanide
  • duofas
  • flukanide
  • Rafoxanide 0.1
  • N-[3-chloro-4-(4-chlorophenoxy)phenyl]-3,5-diiodobenzamide
  • Disalan
CAS:
22662-39-1
MF:
C19H11Cl2I2NO3
MW:
626.01
EINECS:
245-148-9
Product Categories:
  • Used to kill trematode medicine
  • API
  • Rafoxanide
  • 22662-39-1
Mol File:
22662-39-1.mol
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Rafoxanide Chemical Properties

Melting point:
168-170°
Boiling point:
526.6±50.0 °C(Predicted)
Density 
2.050±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
pka
6.04±0.48(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,8097
InChI
InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChIKey
NEMNPWINWMHUMR-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(OC2=CC=C(Cl)C=C2)C(Cl)=C1)(=O)C1=CC(I)=CC(I)=C1O
CAS DataBase Reference
22662-39-1(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
RTECS 
VN7870000
HS Code 
2924.29.7790
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Rafoxanide Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

Rafoxanide is a thyroid hormone receptor.

in vivo

Rafoxanide (7.5 mg/kg, i.p., once every 2 d for 88d) reduces colonic tumorgenesis in Apcmin/+ mice[3].

Animal Model:AOM induced Apcmin/+ mice[3]
Dosage:7.5 mg/kg
Administration:Intraperitoneal injection (i.p.), once every 2 d for 88d
Result:Exerted less number and size of AOM induced lesions in the colon. No significant body weight changes were observed.
Detected adenomas (28.6%), advanced adenomas (67.8%) and adenocarcinoma (3.6%) in control group as adenomas (33.3%), advanced adenomas (25%%) and no obvious lesions(41.6%) were detected in treated group.
Caused increased signal for p-eIF2α, CHOP and cleaved caspase-3 in tumor tissues while these signal in non-tumor colon epithelium were barely detectable.

IC 50

Schistosome

RafoxanideSupplier

Hubei Yangyi Xinsheng Biological Medicine Co., LTD Gold
Tel
15927387803; 15927387803
Email
2263659332@qq.com
Shaanxi Hanjiang Pharmaceutical Group Co., Ltd. Gold
Tel
0916-2225518
Email
api@sxhjp.com
Wuhan Xinru Chemical Co., Ltd. Gold
Tel
15927387915 15337108568
Email
2769903731@qq.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
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