MENTHYL SALICYLATE Chemical Properties

Melting point:

<25 °C

Boiling point:

186-190 °C/12 mmHg (lit.)

Density 

1.04 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.52

Flash point:

100℃

pka

8.10±0.30(Predicted)

Specific Gravity

1.05

Odor

Odorless or slight fruity odor

BRN 

3097754

Stability:

Stable. Incompatible with strong oxidizing agents. Combustible.

LogP

6.429 (est)

EPA Substance Registry System

Benzoic acid, 2-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, rel- (89-46-3)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

MENTHYL SALICYLATE Usage And Synthesis

Description

Menthyl salicylate is almost odorless when pure. Slightly bitter-astringent taste. It carries the usual characteristics of a phenol, which are not exactly welcome by the perfumer.

Chemical Properties

colourless to light yellow liquid

Uses

light stabilizer

Uses

Menthyl salicylate is an ester of menthol and salicylic acid. This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains). It also as a "sun screen" to filter out ultraviolet light in Preparations for preventing sunburn.

Preparation

Menthyl salicylate is produced by azeotropic esterification of Menthol with Salicylic acid, using a Benzene- or Toluene sulfonic acid catalyst.

IC 50

Rat SRD5A1=17.12 μM.^[1]

References

[1] WANYU LI, YIYAN WANG*   Endocrine-Disrupting Effects of Salicylate Preservatives on Neurosteroidogenesis: Targeting 5α-Reductase Type 1[J]. Journal of Agricultural and Food Chemistry, 2024, 72 44: 24797-24807 24797-24807. DOI:10.1021/acs.jafc.4c0426510.1021/acs.jafc.4c04265.

MENTHYL SALICYLATE(89-46-3)Related Product Information

• Isoamyl benzoate
• ISOBUTYL BENZOATE
• BENZOIC ACID 2-ETHYLHEXYL ESTER
• 2-Hydroxybenzoic acid octyl ester
• Isopropyl salicylate
• Isobutyl salicylate
• BENZYL ISOAMYL ETHER
• Butyl salicylate
• Hexyl salicylate
• ISOAMYL SALICYLATE
• SALICYLIC ACID N-PROPYL ESTER
• 2-Ethylhexyl salicylate
• Amyl salicylate
• MENTHYL SALICYLATE
• Ethyl 2-hydroxybenzoate
• cyclohexyl benzoate
• ISOPROPYLCYCLOHEXANE
• ACETIC ACID 2-ISOPROPYL-5-METHYLHEXYL ESTER