κ-Carrageenan
κ-Carrageenan Basic information
- Product Name:
- κ-Carrageenan
- Synonyms:
-
- kappa-carrageen
- CARRAGEENAN
- CARRAGEENAN, KAPPA TYPE
- CARRAGEENAN, LAMBDA TYPE
- CARRAGEENAN TYPE III
- LAMBDA-CARRAGEENAN
- IRISH MOSS
- IRISH MOSS TYPE III
- CAS:
- 11114-20-8
- MF:
- C24H36O25S2-2
- MW:
- 788.65764
- EINECS:
- 234-350-2
- Product Categories:
-
- thickener
- Biochemistry
- Polysaccharides
- Sugars
- Mol File:
- 11114-20-8.mol
κ-Carrageenan Chemical Properties
- solubility
- H2O: 5 mg/mL hot, soluble
- form
- Solid
- color
- White to almost white to yellow to brownish
- biological source
- plant
- Water Solubility
- H2O: soluble 5mg/mL (hot)
- Merck
- 14,1864
Safety Information
- WGK Germany
- 2
- RTECS
- FI0704000
- F
- 3
- HS Code
- 13023990
- Toxicity
- rabbit,LDLo,intravenous,3mg/kg (3mg/kg),BLOOD: CHANGE IN CLOTTING FACTORS,Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 647, 1965.
MSDS
- Language:English Provider:SigmaAldrich
κ-Carrageenan Usage And Synthesis
Uses
κ-Carrageenan is a sulfated linear polysaccharide of D-galactose and 3,6-anhydro-D-galactose extracted from certain red seaweeds of the Rhodophyceae class. κ-Carrageenan is used in the food industry as thickening, gelling and protein-suspending agents, and by the pharmaceutical industry in pills and tablets.
Chemical Properties
sulfate content 20-36%, forms gels powder
Uses
The carrageenans are sulphate gums found in members of the Rhodophyceae. They consist of mixtures of polysaccharides which are mainly composed of D-galactose units linked 1~3 and 1~4. A high proportion ofthe units are substituted with sulphate half-ester groups. The carrageenans are useful stabilisers in foods.
Uses
κ-?Carrageenan is a sulfated linear polysaccharide of D-?galactose and 3,?6-?anhydro-?D-?galactose extracted from certain red seaweeds of the Rhodophyceae class. κ-?Carrageenan is used in the food industry as thickening, gelling and protein-?suspending agents, and by the pharmaceutical industry in pills and tablets.
Definition
A naturally occurringpolysaccharide isolated from redalgae. The polymer is composed of dgalactoseunits, many of which aresulphated. K-carrageenan is a gellingagent with uses similar to those ofagar.
in vivo
κ-Carrageenan can be used in animal modeling to create paw edema, colitis, and thrombosis models. κ-Carrageenan has oral activity; after oral administration, its concentration in BALB/c mice peaks at 3 hours, with an average residence time of 36.6 hours and a clearance rate of 0.1 L/h/kg. Most of the κ-Carrageenan is excreted via feces, while 9.2% is excreted through urine, indicating rapid absorption, slow elimination, and prolonged retention in the body. Additionally, κ-Carrageenan accumulates in the liver and kidneys. After 14 days of oral administration of κ-Carrageenan, hepatocyte necrosis, renal tubular vacuolation, and incomplete colonic epithelial cells are observed. Four hours after intraperitoneal injection of κ-Carrageenan, minor infarcts and erythema appear at the tips of rat tails, with infarct length increasing in a time-dependent manner and stabilizing 24 hours post-injection. Twenty-four hours is determined as the time point for successful establishment of the thrombosis model[4][5][6][7][8][9].
Administration: 0.1 mL ? sc ? single dose
Molecular changes: Neutrophil migration to the foot area of rats injected with κ-carrageenan, along with elevated expression levels of pro-inflammatory factors such as bradykinin, histamine, tachykinins, complement, and reactive oxygen species.
Administration: 1.7, 8.3, 41.7 mg/kg ? po ? single dose
Molecular changes: Significant upregulation of IL-2, TNF-α, and IL-6 expression, with a notable decrease in IL-10 expression. The enzymatic activity of SOD and GSH-px in the colonic mucosa is reduced, while the expression of TLR4, NF-κB, p-ERK, p-JNK, p-Jun, IL-8, and MDA is upregulated.
Administration: 20 mg/kg ? ip ? single dose
Coagulation parameter changes: In the tails of rats with thrombus formation, prothrombin time (PT) and fibrinogen (FIB) significantly increased, while thrombin time (TT) significantly decreased, as determined by classical coagulation testing methods.
| Animal Model: | Male and female NIH (s) mice[2] |
| Dosage: | 1.7?mg/kg, LOW; 8.3?mg/kg, MED; or 41.7?mg/kg, HIG |
| Administration: | Orally administered for 1 week prior to C. freundii DBS100 treatment |
| Result: | Enhanced the C. freundii DBS100-dependent induction of TLR4 and NF-κB in the intestinal mucosa of infected mice. |
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κ-Carrageenan(11114-20-8)Related Product Information
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