4-Fluorobenzoic acid Chemical Properties

Melting point:

182-184 °C (lit.)

Boiling point:

117 °C

Density 

1.479

storage temp. 

Sealed in dry,Room Temperature

solubility 

alcohol: soluble

form 

Crystalline Powder

pka

4.15(at 25℃)

color 

White to slightly yellow

Water Solubility 

Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water.

Merck 

14,4171

BRN 

1906922

InChIKey

BBYDXOIZLAWGSL-UHFFFAOYSA-N

CAS DataBase Reference

456-22-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 4-fluoro-(456-22-4)

EPA Substance Registry System

Benzoic acid, 4-fluoro- (456-22-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-41-36/37/38

Safety Statements 

26-39-24/25-22-37/39-36

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29163900

MSDS

• Language:English Provider:4-Fluorobenzoic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Fluorobenzoic acid Usage And Synthesis

Description

4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the ¹⁸F labeling of antibodies. It has been used in high resolution charge density study.

Reference

AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorobenzoic acid has been used in high resolution charge density study.

Definition

ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4.

Purification Methods

Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.]

4-Fluorobenzoic acid(456-22-4)Related Product Information

• 4-Fluorobenzonitrile
• Stearic acid
• 4-Bromofluorobenzene
• Folic acid
• 4-Fluorobenzamide
• 4-Fluorobenzaldehyde
• 4-Fluoroanisole
• Florfenicol
• 4-(4-Fluorobenzoyl)butyric acid
• Methyl 4-fluorobenzoate
• 2,6-Difluorobenzoic acid
• Ethyl 4-fluorobenzoate
• Transfluthrin
• Ethyl 2-(Chlorosulfonyl)acetate
• 2,4,5-Trifluorobenzoic acid
• Citric acid
• 4-Fluorobenzyl alcohol
• Ascoric Acid