2,4-Dibromo-1-fluorobenzene Chemical Properties

Melting point:

69°C

Boiling point:

105-110 °C (22 mmHg)

Density 

2.047 g/mL at 25 °C(lit.)

refractive index 

1.582-1.584

Flash point:

92 °C

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

color 

Clear colorless

Specific Gravity

2.047

Water Solubility 

insoluble

BRN 

1934822

CAS DataBase Reference

1435-53-6(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Dibromo-1-fluorobenzene(1435-53-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29036990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Dibromo-1-fluorobenzene Usage And Synthesis

Chemical Properties

clear colorless liquid

Synthesis

The general procedure for synthesizing 2,4-dibromofluorobenzene from 2-fluoro-5-bromobenzoic acid is as follows: in Example 6, bromoisocyanurate was used to induce the bromination reaction of aromatic carboxylic acids. This was done as follows: a mixture of 2-fluoro-5-bromobenzoic acid (1 mmol), bromoisocyanuric acid ester, additives and solvent (10 mL) was stirred under fluorescent room light (FL) or warm white 3W LED (LL) irradiation. Upon completion of the reaction, the reaction mixture is washed with 1 M aqueous Na2SO3, dried over Na2SO4, filtered through a short pad of neutral alumina, and concentrated under vacuum to give crude 2,4-dibromofluorobenzene. The crude product can be purified by silica gel chromatography as required. The experimental results are detailed in Table 5.

References

[1] Patent: WO2017/60905, 2017, A1. Location in patent: Paragraph 00139; 00153

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