dendrobine Chemical Properties

Melting point:

135-136℃

Boiling point:

375℃

Density 

1.101

Flash point:

133℃

storage temp. 

4°C, protect from light

solubility 

≥60mg/ml in MeOH

form 

Powder

pka

9.49±0.60(Predicted)

Safety Information

HS Code 

29399990

dendrobine Usage And Synthesis

Description

Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.

Uses

Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.

Definition

ChEBI: Dendrobine is a member of indoles.

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