4'-Fluoro-2'-hydroxyacetophenone Chemical Properties

Melting point:

32-34°C

Boiling point:

65°C 2mm

Density 

1.1850 (estimate)

Flash point:

98°C

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to lump

pka

9.17±0.10(Predicted)

color 

White to Almost white

BRN 

2249799

InChIKey

HLTBTUXAMVOKIH-UHFFFAOYSA-N

CAS DataBase Reference

1481-27-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29147000

MSDS

• Language:English Provider:ALFA

4'-Fluoro-2'-hydroxyacetophenone Usage And Synthesis

Chemical Properties

Colorless to yellow liquid

Uses

4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.

Preparation

Preparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).

General Description

4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P2₁/n.

4'-Fluoro-2'-hydroxyacetophenone(1481-27-2)Related Product Information

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