8-HYDROXY-7-METHOXYCOUMARIN Chemical Properties

Melting point:

176°C

Boiling point:

381.9±42.0 °C(Predicted)

Density 

1.377

pka

7.78±0.20(Predicted)

BRN 

168393

LogP

0.620 (est)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

2932209090

MSDS

• Language:English Provider:ALFA

8-HYDROXY-7-METHOXYCOUMARIN Usage And Synthesis

Uses

8-Hydroxy-7-methoxycoumarin is a phenylpropanoid isolated from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. 8-Hydroxy-7-methoxycoumarin shows cytotoxicity against GLC4 and COLO 320 cancer cell after continuous incubation (4 days) with IC50s of 179 μM and 145 μM[1][2].

Definition

ChEBI: 8-Hydroxy-7-methoxy-2H-1-benzopyran-2-one is a hydroxycoumarin.

References

[1] HuiLv, et al. Chemical constituents from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. Biochemical Systematics and Ecology, Volume 78, June 2018, Pages 63-65.
[2] H Kolodzie, et al. Structure-cytotoxicity relationships of a series of natural and semi-synthetic simple coumarins as assessed in two human tumour cell lines. Z Naturforsch C J Biosci. 1997 Mar-Apr;52(3-4):240-4. DOI:10.1515/znc-1997-3-416

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