Cyclobutanemethanol Chemical Properties

Melting point:

68.5 °C

Boiling point:

143-144 °C(lit.)

Density 

0.913 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.446(lit.)

Flash point:

104 °F

storage temp. 

Sealed in dry,2-8°C

pka

15.26±0.10(Predicted)

form 

Liquid

color 

Clear colorless

Water Solubility 

immiscible

BRN 

2036027

InChIKey

WPOPOPFNZYPKAV-UHFFFAOYSA-N

CAS DataBase Reference

4415-82-1(CAS DataBase Reference)

NIST Chemistry Reference

Cyclobutanemethanol(4415-82-1)

Safety Information

Risk Statements 

10

Safety Statements 

16-24/25

RIDADR 

UN 1987 3/PG 3

WGK Germany 

3

HazardClass 

3

PackingGroup 

III

HS Code 

29061900

MSDS

• Language:English Provider:Hydroxymethylcyclobutane
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Cyclobutanemethanol Usage And Synthesis

Chemical Properties

Colorless to Almost colorless clear liquid.

Uses

Cyclobutanemethanol was used in the synthesis of bicyclic lactone.

Application

Cyclobutanemethanol is a drug used to treat inflammatory diseases. It is an uptake inhibitor that blocks the transport of uridine into cells, preventing the activation of G-protein coupled receptors and the subsequent production of inflammatory mediators. Cyclobutanemethanol has been shown to have anti-inflammatory properties by inhibiting the CB2 receptor, which is found in large quantities in inflammatory tissues. It also prevents dehydration and increases blood flow to inflamed areas by acting on vascular endothelial cells. It has been shown to inhibit influenza virus replication in vitro, but not in vivo.

General Description

Oxidation of cyclobutanemethanol in the presence of lead tetraacetate and lead tetraacetate/metal chloride has been investigated.

Synthesis

Cyclobutanemethanol can be synthesized from two molecules of hydrochloric acid and one molecule of cyclobutane. The synthesis pathway includes removal of a hydroxy group and addition of an alkynyl group via hydrogen bonding interactions with chloride ions.

Cyclobutanemethanol(4415-82-1)Related Product Information

• Acetoin
• Cyclobutyl bromide
• Tetrabutylammonium bromide
• Diisobutylcarbinol
• butyl rubber
• Methanol
• Cyclobutanecarboxaldehyde
• Tributyltin chloride
• Cyclopentanemethanol
• 1,1-Bis(hydroxymethyl)cyclopropane
• 1,1-Cyclobutanedicarboxylic acid
• tert-Butyl methyl ether
• Cyclobutane-1,2,3,4-tetracarboxylic dianhydride
• Cyclobutanecarboxylic acid
• Cyclopropyl carbinol
• Cyclobutylmethylamine
• CYCLOBUTYLBORONIC ACID
• Cyclobutanecarbonyl chloride