Isoconazole nitrate
Isoconazole nitrate Basic information
- Product Name:
- Isoconazole nitrate
- Synonyms:
-
- 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrate
- 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate
- 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI)
- Adestan G 100
- Fazol
- Gyno-Travogen
- Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI)
- R 15454
- CAS:
- 24168-96-5
- MF:
- C18H15Cl4N3O4
- MW:
- 479.14
- EINECS:
- 246-051-4
- Product Categories:
-
- Inhibitors
- Aromatics
- Antifungal
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 24168-96-5.mol
Isoconazole nitrate Chemical Properties
- Melting point:
- 178-182°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
- form
- Solid
- color
- White to Off-White
- Merck
- 14,5160
- CAS DataBase Reference
- 24168-96-5(CAS DataBase Reference)
Isoconazole nitrate Usage And Synthesis
Chemical Properties
White Solid
Originator
Fazol,Fournier,France,1979
Uses
Antibacterial; antifungal
Uses
Isoconazole Nitrate acts as an antibacterial in the local treatment of vaginitis; antifungal agent (1,2).
Manufacturing Process
To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.
Therapeutic Function
Antibacterial, Antifungal
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Isoconazole nitrate (24168-96-5)Related Product Information
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- Miconazole nitrate
- Ethanol
- Ethyl acetate
- 4-Methoxyphenylacetone
- Ethylparaben
- Ethyl cyanoacetate
- NITRATE
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- p-Anisidine
- ISOXADIFEN-ETHYL
- p-(2-Methoxyethyl) phenol
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- Miconazole Nitrate
- Methoxydiethylborane
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- Anisole