Isoconazole nitrate Chemical Properties

Melting point:

178-182°C

storage temp. 

Sealed in dry,2-8°C

solubility 

Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).

color 

White to Off-White

Merck 

14,5160

CAS DataBase Reference

24168-96-5(CAS DataBase Reference)

Safety Information

RTECS 

NI4772000

HS Code 

2933.29.4300

Isoconazole nitrate Usage And Synthesis

Chemical Properties

White Solid

Originator

Fazol,Fournier,France,1979

Uses

Antibacterial; antifungal

Uses

Isoconazole Nitrate acts as an antibacterial in the local treatment of vaginitis; antifungal agent (1,2).

Manufacturing Process

To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.

Therapeutic Function

Antibacterial, Antifungal

Isoconazole nitrate (24168-96-5)Related Product Information

• (Trifluoromethoxy)benzene
• Miconazole nitrate
• Ethanol
• Ethyl acetate
• 4-Methoxyphenylacetone
• Ethylparaben
• Ethyl cyanoacetate
• NITRATE
• Thiamine nitrate
• p-Anisidine
• ISOXADIFEN-ETHYL
• p-(2-Methoxyethyl) phenol
• Econazole nitrate
• Dichlorodiphenylsilane
• Miconazole Nitrate
• Methoxydiethylborane
• Dichloromethylphenylsilane
• Anisole