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4-Aminohippuric acid

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4-Aminohippuric acid Basic information

Product Name:
4-Aminohippuric acid
Synonyms:
  • |p|-AMinohippuric acid (PAH)
  • 2-[(4-aminophenyl)carbonylamino]ethanoic acid
  • 2-[[(4-aminophenyl)-oxomethyl]amino]acetic acid
  • Aminohippuric acid [USAN]
  • Hippuric acid, p-amino-
  • Hippuric acid, p-amino- (8CI)
  • Nefrotest
  • N-[(4-aminophenyl)carbonyl]glycine
CAS:
61-78-9
MF:
C9H10N2O3
MW:
194.19
EINECS:
200-518-9
Product Categories:
  • TRASENTINE
  • Amino Acids
Mol File:
61-78-9.mol
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4-Aminohippuric acid Chemical Properties

Melting point:
199-200 °C (dec.)(lit.)
Boiling point:
330.62°C (rough estimate)
Density 
1.356
refractive index 
1.5600 (estimate)
storage temp. 
Store below +30°C.
solubility 
DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml
form 
Crystalline Powder
pka
pKa 3.8 (Uncertain)
color 
Off-white to grayish
PH
3.0-3.5 (20g/l, H2O, 20℃)
Water Solubility 
Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride.
Merck 
14,442
BRN 
1213676
InChIKey
HSMNQINEKMPTIC-UHFFFAOYSA-N
CAS DataBase Reference
61-78-9(CAS DataBase Reference)
EPA Substance Registry System
P-Aminohippuric acid (61-78-9)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
37/39-26-36
WGK Germany 
3
8-9-23
TSCA 
Yes
HS Code 
29242990
Hazardous Substances Data
61-78-9(Hazardous Substances Data)

MSDS

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4-Aminohippuric acid Usage And Synthesis

Description

4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.

Chemical Properties

off-white to greyish crystalline powder

Uses

muscle relaxant (smooth)

Uses

p-Aminohippuric acid has been used as infusions to measure plasma flow.

Uses

4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.

Definition

ChEBI: An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.

General Description

Renal tubules secretes para amino hippuric acid/PAH.

Biochem/physiol Actions

Para-aminohippuric acid?(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.

Purification Methods

Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]

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