4-Aminohippuric acid
4-Aminohippuric acid Basic information
- Product Name:
- 4-Aminohippuric acid
- Synonyms:
-
- |p|-AMinohippuric acid (PAH)
- 2-[(4-aminophenyl)carbonylamino]ethanoic acid
- 2-[[(4-aminophenyl)-oxomethyl]amino]acetic acid
- Aminohippuric acid [USAN]
- Hippuric acid, p-amino-
- Hippuric acid, p-amino- (8CI)
- Nefrotest
- N-[(4-aminophenyl)carbonyl]glycine
- CAS:
- 61-78-9
- MF:
- C9H10N2O3
- MW:
- 194.19
- EINECS:
- 200-518-9
- Product Categories:
-
- TRASENTINE
- Amino Acids
- Mol File:
- 61-78-9.mol
4-Aminohippuric acid Chemical Properties
- Melting point:
- 199-200 °C (dec.)(lit.)
- Boiling point:
- 330.62°C (rough estimate)
- Density
- 1.356
- refractive index
- 1.5600 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml
- form
- Crystalline Powder
- pka
- pKa 3.8 (Uncertain)
- color
- Off-white to grayish
- PH
- 3.0-3.5 (20g/l, H2O, 20℃)
- Water Solubility
- Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride.
- Merck
- 14,442
- BRN
- 1213676
- InChIKey
- HSMNQINEKMPTIC-UHFFFAOYSA-N
- CAS DataBase Reference
- 61-78-9(CAS DataBase Reference)
- EPA Substance Registry System
- P-Aminohippuric acid (61-78-9)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- F
- 8-9-23
- TSCA
- Yes
- HS Code
- 29242990
- Hazardous Substances Data
- 61-78-9(Hazardous Substances Data)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
4-Aminohippuric acid Usage And Synthesis
Description
4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.
Chemical Properties
off-white to greyish crystalline powder
Uses
muscle relaxant (smooth)
Uses
p-Aminohippuric acid has been used as infusions to measure plasma flow.
Uses
4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.
Definition
ChEBI: An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.
General Description
Renal tubules secretes para amino hippuric acid/PAH.
Biochem/physiol Actions
Para-aminohippuric acid?(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.
Purification Methods
Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]
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4-Aminohippuric acid(61-78-9)Related Product Information
- L-Tetrahydrofolic Acid
- Folic acid
- Aminopterin
- P-NITROBENZOYL-L-GLUTAMIC ACID
- 4-Aminohippuric acid
- P-AMINOHIPPURIC ACID SODIUM SALT
- N-(p-Aminobenzoyl)glutamic acid
- METHOTREXATE HYDRATE
- 5-METHYLTETRAHYDROFOLIC ACID DISODIUM SALT
- diethyl N-[4-(methylamino)benzoyl]-L-glutamate
- DIHYDROFOLIC ACID
- N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID DIETHYL ESTER
- 4-NITROHIPPURIC ACID
- Calcium folinate
- (+/-)AMETHOPTERIN
- P-AMINOHIPPURIC ACID SODIUM
- Hippuric acid
- Uric acid