4-Ethynylanisole Chemical Properties

Melting point:

28-29 °C (lit.)

Boiling point:

87-91 °C/11 mmHg (lit.)

Density 

1.019 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.563(lit.)

Flash point:

180 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Acetontrile (Slightly), Chloroform (Slightly)

form 

Liquid or Low Melting Solid

color 

Clear colorless to deep yellow or brown

Water Solubility 

Insoluble in water. Soluble in chloroform, acetone, dichloromethane, and methanol.

Sensitive 

Light Sensitive

Stability:

Light and Temperature Sensitive

InChIKey

KBIAVTUACPKPFJ-UHFFFAOYSA-N

CAS DataBase Reference

768-60-5(CAS DataBase Reference)

NIST Chemistry Reference

4-CH3O-C6H4-CCH(768-60-5)

Safety Information

Hazard Codes 

Xn,F

Risk Statements 

22

Safety Statements 

24/25

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

PackingGroup 

II

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich

4-Ethynylanisole Usage And Synthesis

Chemical Properties

Pale Yellow Oil

Uses

Intermediate in the synthesis of histamine H3-receptor antagonists. Also utilized to prepare its luminescent copper complex

Uses

1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.1

Uses

4-Ethynylanisole was used in the synthesis of photo luminescent 1,2-dihydrophosphinines via a [4 + 2] cycloaddition. Along with an arylboronic acid and sodium azide in a copper-catalyzed, three-component synthesis of trisubstituted 1,2,4-triazoles. In a study of a gold (III)-catalyzed hydroamination of alkynes leading to N-vinylindoles3.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: 1-Eth-1-ynyl-4-methoxybenzene is a member of methoxybenzenes.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 9, p. 230, 1998
Synthesis, p. 305, 1978
Tetrahedron, 62, p. 6673, 2006 DOI: 10.1016/j.tet.2005.12.077

General Description

4-Ethynylanisole forms the corresponding propargyl aldehyde in good yield directly from DMF-dimethyl acetal without the need for making an acetylide salt. 1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.

4-Ethynylanisole(768-60-5)Related Product Information

• 4'-Methoxyacetophenone
• 1-(4-Methoxyphenyl)piperazine
• p-Anisidine
• 1-BUTEN-3-YNE
• Trimethylsilylacetylene
• 4-Methylanisole
• (Trifluoromethoxy)benzene
• 4-Methoxyphenol
• 3-Methoxybenzaldehyde
• Anisole
• 4-Methoxyphenylacetone
• 4-Methoxybenzylchloride
• p-Anisaldehyde
• 1-Butoxy-4-eth-1-ynylbenzene
• 4-n-Propoxyphenylacetylene
• 1-Ethyl-4-[(4-Methoxyphenyl)ethynyl]benzene
• 1-Eth-1-ynyl-4-(pentyloxy)benzene
• 3-(4-METHOXY-PHENYL)-PROP-2-YN-1-OL