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2-Nitrophenylacetonitrile

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2-Nitrophenylacetonitrile Basic information

Product Name:
2-Nitrophenylacetonitrile
Synonyms:
  • (o-nitrophenyl)-acetonitril
  • 2-nitro-benzeneacetonitril
  • 2-nitrobenzeneacetonitrile
  • 2-nitrobenzylnitrile
  • 2-nitro-2-phenylacetonitrile
  • o-nitrobenzacetonitrile
  • O-NITROBENZYL CYANIDE
  • 2-Nitrophenylacetonitrile 98%
CAS:
610-66-2
MF:
C8H6N2O2
MW:
162.15
EINECS:
210-231-0
Product Categories:
  • Building Blocks
  • C8 to C9
  • benzene derivative
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Aromatic Nitriles
  • Aromatics
  • C8 to C9
  • Cyanides/Nitriles
  • Nitrogen Compounds
Mol File:
610-66-2.mol
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2-Nitrophenylacetonitrile Chemical Properties

Melting point:
82-85 °C(lit.)
Boiling point:
178°C
Density 
1.3264 (rough estimate)
refractive index 
1.5770 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Ethyl Acetate
form 
Powder
color 
Light brown to brownish-gray
Water Solubility 
<0.01 g/100 mL at 20 ºC
BRN 
1869400
Exposure limits
NIOSH: IDLH 25 mg/m3
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
610-66-2(CAS DataBase Reference)
EPA Substance Registry System
o-Nitrophenylacetonitrile (610-66-2)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-24/25
RIDADR 
3439
WGK Germany 
3
RTECS 
AM1248000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090

MSDS

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2-Nitrophenylacetonitrile Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

2-Nitrophenylacetonitrile was used in synthesis of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones. It was used in the synthesis of strychnine.

Synthesis Reference(s)

Synthesis, p. 514, 1987 DOI: 10.1055/s-1987-27989

General Description

Light brown solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Nitriles, such as 2-Nitrophenylacetonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Fire Hazard

Flash point data for 2-Nitrophenylacetonitrile are not available. 2-Nitrophenylacetonitrile is probably combustible.

2-Nitrophenylacetonitrile Preparation Products And Raw materials

Preparation Products

2-NitrophenylacetonitrileSupplier

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