2-Nitrophenylacetonitrile Chemical Properties

Melting point:

82-85 °C(lit.)

Boiling point:

178°C

Density 

1.3264 (rough estimate)

refractive index 

1.5770 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Ethyl Acetate

form 

Powder

color 

Light brown to brownish-gray

Water Solubility 

<0.01 g/100 mL at 20 ºC

BRN 

1869400

Exposure limits

NIOSH: IDLH 25 mg/m3

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

610-66-2(CAS DataBase Reference)

EPA Substance Registry System

o-Nitrophenylacetonitrile (610-66-2)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36-24/25

RIDADR 

3439

WGK Germany 

3

RTECS 

AM1248000

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:o-Nitrobenzyl cyanide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Nitrophenylacetonitrile Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

2-Nitrophenylacetonitrile was used in synthesis of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones. It was used in the synthesis of strychnine.

Synthesis Reference(s)

Synthesis, p. 514, 1987 DOI: 10.1055/s-1987-27989

General Description

Light brown solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Nitriles, such as 2-Nitrophenylacetonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Fire Hazard

Flash point data for 2-Nitrophenylacetonitrile are not available. 2-Nitrophenylacetonitrile is probably combustible.

2-Nitrophenylacetonitrile(610-66-2)Related Product Information

• Diphenylacetonitrile
• 2-Nitrobenzaldehyde
• 4-Methylbenzyl cyanide
• 1-Chloro-3-nitrobenzene
• Sodium 3-nitrobenzenesulphonate
• 2-Nitrobenzoic acid
• 2-Nitrotoluene
• Copper(I) Cyanide
• 4-Nitrobenzoic acid
• (3-Methoxyphenyl)acetonitrile
• 2-Methylbenzyl cyanide
• 2-Nitrophenylacetic acid
• 2-Nitrobenzyl alcohol
• 2-Nitroacetophenone
• 2-Nitrophenol
• Benzeneacetonitrile
• POTASSIUM CYANIDE
• HYDROGEN CYANIDE