Tebufenpyrad Chemical Properties

Melting point:

61-62°

Boiling point:

468.4±45.0 °C(Predicted)

Density 

1.1639 (rough estimate)

refractive index 

1.5790 (estimate)

storage temp. 

0-6°C

solubility 

Benzene (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

13.19±0.46(Predicted)

form 

solid

BRN 

8636471

InChI

InChI=1S/C18H24ClN3O/c1-6-14-15(19)16(22(5)21-14)17(23)20-11-12-7-9-13(10-8-12)18(2,3)4/h7-10H,6,11H2,1-5H3,(H,20,23)

InChIKey

ZZYSLNWGKKDOML-UHFFFAOYSA-N

SMILES

N1(C)C(C(NCC2=CC=C(C(C)(C)C)C=C2)=O)=C(Cl)C(CC)=N1

LogP

4.610

CAS DataBase Reference

119168-77-3(CAS DataBase Reference)

EPA Substance Registry System

Tebufenpyrad (119168-77-3)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

RIDADR 

2588

WGK Germany 

3

RTECS 

UQ6276400

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29331990

Hazardous Substances Data

119168-77-3(Hazardous Substances Data)

Toxicity

LD50 in male, female rats (mg/kg): 595, 997 orally; >2000, >2000 dermally; LC50 in male rats (mg/m3): 2660 by inhalation (Inoue, Fukuchi)

Tebufenpyrad Usage And Synthesis

Chemical Properties

Tan Solid

Uses

Tebufenpyrad is a pyrazole acaricide and insecticide commonly used in commercial greenhouses.

Uses

Acaricide.

Definition

ChEBI: Tebufenpyrad is a pyrazole acaricide and a pyrazole insecticide. It has a role as a mitochondrial NADH:ubiquinone reductase inhibitor.

Metabolic pathway

By incubation of tebufenpyrad with rat liver homogenate, tebufenpyrad undergoes biotransformation to yield the major metabolites N-(4- tert-butylbenzyl)-4-chloro-3-(1-hydroxyethyl)-1- methylpyrazole-5-carboxamide via hydroxylation of the w-1-carbon of the ethyl group and N-[4-(1-carboxy-1- methylethyl)benzyl]-4-chloro-3-ethyl-1-methylpyrazole- 5-carboxamide via oxidation of the methyl group in the tert-butyl moiety to the carboxylic acid derivatives.
When the rat is orally dosed tebufenpyrad, the major metabolism pathway is via both hydroxylation and oxidation reactions to yield N-[4-(1-carboxy-1- methylethyl)benzyl]-4-chloro-3-(1-hydroxyethyl)-1- methylpyrazole-5-carboxamide which is mainly excreted in the urine.

Tebufenpyrad(119168-77-3)Related Product Information

• Fenpyroximate
• Fenbutatin oxide
• Bromopropylate
• FLUFENZINE
• Propargite
• ETOXAZOLE
• ACEQUINOCYL
• Fenazaquin
• Clofentezine
• Azocyclotin
• Benzoximate
• Machette
• 1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXAMIDE
• (1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYLAMINE
• Tebufenpyrad
• N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE
• 4-CHLORO-2-METHYL-2 H-PYRAZOLE-3-CARBALDEHYDE
• 1H-Pyrazole-3-carboxamide, N-ethyl-5-methyl-