5,4'-DIHYDROXYFLAVONE Chemical Properties

Melting point:

239-240°C

Boiling point:

486.0±45.0 °C(Predicted)

Density 

1.443±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 155 mg/mL (609.66 mM);Water : < 0.1 mg/mL (insoluble)

pka

6.78±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

5,4'-DIHYDROXYFLAVONE Usage And Synthesis

Uses

4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1.

References

[1] Ribeiro D, et al. Inhibition of LOX by flavonoids: a structure-activity relationship study. Eur J Med Chem. 2014 Jan 24;72:137-45. DOI:10.1016/j.ejmech.2013.11.030
[2] Proen?a C, et al. α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228. DOI:10.1080/14756366.2017.1368503

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