N-Benzyltropinone Chemical Properties

Melting point:

28-29°C

Boiling point:

134-137°C/0.4 mm

Density 

1.140±0.06 g/cm3(Predicted)

refractive index 

1.556

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Dichloromethane, Methanol

form 

Solid

pka

7.98±0.20(Predicted)

color 

Off-White to Pale Yellow

InChI

InChI=1S/C14H17NO/c16-14-8-12-6-7-13(9-14)15(12)10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2

InChIKey

RSUHKGOVXMXCND-UHFFFAOYSA-N

SMILES

C12N(CC3=CC=CC=C3)C(CC1)CC(=O)C2

CAS DataBase Reference

28957-72-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

23-26-36/37/39-45

RIDADR 

UN1760

HazardClass 

8

HS Code 

29299090

MSDS

• Language:English Provider:8-Benzyl-8-azabicyclo[3.2.1]octan-3-one

N-Benzyltropinone Usage And Synthesis

Chemical Properties

Off-White to Pale Yellow Low-Melting Solid

Uses

An intermediate for the preparation of β-Cocaine, opioid receptor antagonists, and CCR-5 receptor antagonists

Synthesis

1. To a non-homogeneous solution of 2,5-dimethoxytetrahydrofuran (82.2 g, 0.622 mol) in water (170 mL) was slowly added concentrated hydrochloric acid (30 mL) under stirring conditions. 2. In another flask, benzylamine (100 g, 0.933 mol) was dissolved in water (350 mL), cooled to 0 °C (ice bath) and concentrated hydrochloric acid (92 mL) was added slowly. 3. The 2,5-dimethoxytetrahydrofuran solution was stirred for 20 minutes and diluted with water (250 mL), followed by the sequential addition of the benzylamine solution, an aqueous (400 mL) solution of 1,3-acetone dicarboxylic acid (100 g, 0.684 mol), and an aqueous (200 mL) solution of sodium hydrogensulphate (44 g, 0.31 mol). 4. the pH of the reaction mixture was adjusted from 1 to about 4.5 using a 40% NaOH solution. 5. The resulting cloudy light yellow solution was stirred overnight. 6. The solution was acidified from pH 7.5 to 3 with 50% hydrochloric acid, heated to 85°C and stirred for 2 hours. 7. After cooling to room temperature, the solution was alkalized to pH 12 with 40% NaOH solution and extracted with dichloromethane (3 x 500 mL). 8. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title intermediate as a viscous brown oil (~95% purity based on HPLC analysis). 9. The structure of the product was confirmed by 1H-NMR (CDCl3) and mass spectrometry ([M+H]+ C14H17NO calculated value 216.14; measured value 216.0).

References

[1] Patent: US2006/135764, 2006, A1. Location in patent: Page/Page column 22-23
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 18
[3] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 23
[4] Patent: US2007/167442, 2007, A1. Location in patent: Page/Page column 40
[5] Patent: US2007/219278, 2007, A1. Location in patent: Page/Page column 15

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