5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Basic information
- Product Name:
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- Synonyms:
-
- 1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid
- Fmoc-NH-PEG5-CH2CO2H
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- FMoc-NH-PEG4-CH2COOH
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
- Fmoc-NH-PEG4-CH2CO2H
- Fmoc-PEG4- CH2COOH
- 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
- CAS:
- 437655-95-3
- MF:
- C25H31NO8
- MW:
- 473.52
- Product Categories:
-
- peg
- Mol File:
- 437655-95-3.mol
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Chemical Properties
- Melting point:
- 51℃
- Boiling point:
- 681.3±55.0 °C(Predicted)
- Density
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Oil
- pka
- 3.39±0.10(Predicted)
- color
- Colorless to light yellow
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Usage And Synthesis
Description
Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
5,8,11,14-Tetraoxa-2-azahexadecanedioic acidSupplier
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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid(437655-95-3)Related Product Information
- N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE
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- 2-[2-(2-methoxyethoxy)ethoxy]ethylamine
- H2N-PEG4-tBu
- OCTAETHYLENE GLYCOL MONOMETHYL ETHER
- 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol
- 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE
- Maleimide-PEG4-NHS Ester
- alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol)
- Hexaethylene glycol
- 2,5,8,11-TETRAOXATRIDECANE-13-THIOL
- FMoc-NH-5(ethylene glycol)-acetic acid
- HO-PEG12-tBu
- N3-PEG4-tBu
- HEPTAETHYLENE GLYCOL MONOMETHYL ETHER
- FmocNH-PEG4-t-butyl acetate
- FmocNH-PEG5-t-butly ester
- FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID