Propargyl--PEG3-phosphonic acid Chemical Properties

Boiling point:

417.2±55.0 °C(Predicted)

Density 

1.266±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM

pka

2.14±0.10(Predicted)

Propargyl--PEG3-phosphonic acid Usage And Synthesis

Description

Propargyl-PEG3-phosphonic acid is a crosslinker containing a propargyl group and a phosphonic acid. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-phosphonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1.

Propargyl--PEG3-phosphonic acid(1714139-62-4)Related Product Information

• Propargyl-PEG3-methyl ester
• Propargyl-PEG3-Sulfone-PEG3-Propargyl
• Propargyl-PEG3-phosphonic acid ethyl ester
• Propargyl-PEG3-Bromide
• Propargyl-PEG4-5-nitrophenyl carbonate
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG3-NH2
• Propargyl-PEG4-(CH2)3-acid
• Propargyl-PEG4-(CH2)3-methyl ester
• Propargyl-PEG3-Ms