Temocaprilat Chemical Properties

Melting point:

>2300C (dec)

alpha 

25D +63.4° (c = 1 in DMF)

Boiling point:

743.6±60.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

2.09±0.10(Predicted)

color 

White to Off-White

Temocaprilat Usage And Synthesis

Description

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀ = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I with an IC₅₀ value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.

Chemical Properties

White to Off-White Solid

Uses

Antihypertensive.

Definition

ChEBI: Temocaprilat is a non-proteinogenic alpha-amino acid.

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