Pyridine-2-carboximidamide hydrochloride Chemical Properties

Melting point:

150-152°C

storage temp. 

Inert atmosphere,Room Temperature

form 

crystals

color 

Off-white

Sensitive 

Hygroscopic

BRN 

3562671

InChI

InChI=1S/C6H7N3.ClH/c7-6(8)5-3-1-2-4-9-5;/h1-4H,(H3,7,8);1H

InChIKey

GMHCEDDZKAYPLB-UHFFFAOYSA-N

SMILES

C(C1N=CC=CC=1)(N)=N.Cl

CAS DataBase Reference

51285-26-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39-37

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:ALFA

Pyridine-2-carboximidamide hydrochloride Usage And Synthesis

Chemical Properties

White solid

Synthesis

General procedure for the synthesis of 2-amidinopyridine hydrochloride from 2-cyanopyridine: 2-cyanopyridine (26.01 g) was reacted with sodium methanol solution at room temperature with stirring for 22 h. Subsequently, ammonium chloride (28.01 g) was added and the reaction was continued for 6 h. The reaction was completed by filtration. After completion of the reaction, the unreacted ammonium chloride was removed by filtration. The filtrate was dried by rotary evaporator to remove the solvent and the resulting residue was washed with methanol to give a light yellow solid powder. It was further washed three times with ether to remove unreacted 2-cyanopyridine. Finally, recrystallization was carried out using mixed ethanol-ether solvent to give 2-amidinopyridine hydrochloride (Compound 2) as a white solid product. Yield: 83%.

References

[1] Patent: CN105399775, 2016, A. Location in patent: Paragraph 0026-0028
[2] Patent: CN103936795, 2016, B. Location in patent: Paragraph 0032-0035
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 9, p. 2600 - 2617
[4] Patent: WO2011/130908, 2011, A1. Location in patent: Page/Page column 53
[5] Patent: WO2011/133444, 2011, A1. Location in patent: Page/Page column 52

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