4-Fluoropyridine hydrochloride Chemical Properties

Melting point:

100 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Water Solubility 

Soluble in water

form 

powder to crystal

color 

White to Almost white

InChI

1S/C5H4FN.ClH/c6-5-1-3-7-4-2-5;/h1-4H;1H

InChIKey

QRUIPALQRYLTAF-UHFFFAOYSA-N

SMILES

Cl.Fc1ccncc1

CAS DataBase Reference

39160-31-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

4-Fluoropyridine hydrochloride Usage And Synthesis

Chemical Properties

Light yellow powder.

Uses

4-Fluoropyridine Hydrochloride is the salt version of 4-Fluoropyridine (B439463(M)), which was useful for studying the interaction of pyridines with OCS.

Synthesis

A suspension of 4-aminopyridine (7.06 g, 75.1 mmol) in 40 mL of anhydrous dichloromethane was stirred at -78??C for 15 min. minutes and added to anhydrous HF (31.2 g, 1.6 ) that had been cooled to -78??C in a polyethylene vial. mol). The reaction mixture was allowed to warm to -5??C and NaNO2 was added in batches over 10 min. (6.22 g, 90.1 mmol) while maintaining the temperature between -5 and 0??C. The mixture was allowed to warm to room temperature and then heated to 40-50??C for 1.5 hours. Dichloromethane (50 mL) was added. After cooling to -10??C, adjust pH to 10 by dropwise addition of 30% aqueous NH4OH over 10 min. filter to break emulsion and extract with dichloromethane. After drying on silica gel, HCl gas was bubbled through the solution. The solvent was evaporated in vacuum to give 4.9 g (37.1 mmol, 50%) of a pale yellow salt.

4-Fluoropyridine hydrochloride(39160-31-1)Related Product Information

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