4-Boc-1-piperazineacetic acid Chemical Properties

Boiling point:

365.5±37.0 °C(Predicted)

Density 

1.174

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.40±0.10(Predicted)

form 

Solid

color 

Off-white to gray

InChI

InChI=1S/C11H20N2O4/c1-11(2,3)17-10(16)13-6-4-12(5-7-13)8-9(14)15/h4-8H2,1-3H3,(H,14,15)

InChIKey

WZBHMXRBXXCEDD-UHFFFAOYSA-N

SMILES

N1(CC(O)=O)CCN(C(OC(C)(C)C)=O)CC1

Safety Information

Hazard Codes 

Xi

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933599590

4-Boc-1-piperazineacetic acid Usage And Synthesis

Uses

1-Boc-4-carboxymethyl piperazine is a PROTAC linker. 1-Boc-4-carboxymethyl piperazine can be used in the synthesis of PROTACs (e.g. PROTAC IRAK4 degrader-12 (HY-168586))[1].

Synthesis

b) General procedure for the synthesis of 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid: to a solution of tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate (1.5 g, 5.51 mmol) in methanol (10 ml) was added an aqueous solution of sodium hydroxide (0.8 g, 22.0 mmol, 4 equiv). The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the mixture was concentrated and extracted according to the method of Intermediate Example 5 (c). The solvent was removed by distillation to give the target product in 76% (1 g) yield. The product was characterized by LC-MS (ESI): calculated mass: 244.29; observed mass: 145.1 [M-Boc + H]+ (retention time: 0.102 min).

References

[1] Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1.WIPO, 2024-10-03.

4-Boc-1-piperazineacetic acid(156478-71-6)Related Product Information

• tert-Butyl peroxyacetate
• Tris(trimethylsilyl)phosphate
• tert-Butanol
• tert-Butyl acetate
• Cyhalofop-butyl
• 1-BENZHYDRYLPIPERAZINE
• tert-Butyl peroxybenzoate
• Ethyl 2-(Chlorosulfonyl)acetate
• Buprofezin
• BUTYL OLEATE
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• Butyl acetate
• Butylparaben
• 2-Ethylhexyl ferulate
• Diisobutyl phthalate
• Isobutyl chloroformate
• 1,2-Dimethylhydrazine Dihydrochloride
• Levodropropizine