2-Amino-5-nitrobenzophenone
2-Amino-5-nitrobenzophenone Basic information
- Product Name:
- 2-Amino-5-nitrobenzophenone
- Synonyms:
-
- (2-amino-5-nitrophenyl)phenyl-methanon
- 2-Amino-5-nitrodiphenylmethone
- 2-Amino-5-nitrodiphenylone
- 2-Benzoyl-4-nitroaniline
- 5-Nitro-2-aminobenzophenone
- Benzophenone, 2-amino-5-nitro-
- Methanone, (2-amino-5-nitrophenyl)phenyl-
- Methanone,(2-amino-5-nitrophenyl)phenyl-
- CAS:
- 1775-95-7
- MF:
- C13H10N2O3
- MW:
- 242.23
- EINECS:
- 217-207-9
- Product Categories:
-
- Building Blocks
- C13 to C14
- Carbonyl Compounds
- Chemical Synthesis
- Organic Building Blocks
- Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- FINE Chemical & INTERMEDIATES
- Aromatic Benzophenones & Derivatives (substituted)
- Various Metabolites and Impurities
- Nitrazepam
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- C13 to C14
- Carbonyl Compounds
- Ketones
- Mol File:
- 1775-95-7.mol
2-Amino-5-nitrobenzophenone Chemical Properties
- Melting point:
- 166-168 °C (lit.)
- Boiling point:
- 385.05°C (rough estimate)
- Density
- 1.2480 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- -2.26±0.36(Predicted)
- color
- Beige
- Water Solubility
- 3 mg/L (20 C)
- InChI
- InChI=1S/C13H10N2O3/c14-12-7-6-10(15(17)18)8-11(12)13(16)9-4-2-1-3-5-9/h1-8H,14H2
- InChIKey
- PZPZDEIASIKHPY-UHFFFAOYSA-N
- SMILES
- C(C1=CC([N+]([O-])=O)=CC=C1N)(C1=CC=CC=C1)=O
- CAS DataBase Reference
- 1775-95-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Methanone, (2-amino-5-nitrophenyl)phenyl-(1775-95-7)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- RTECS
- PC4935000
- HS Code
- 29223990
MSDS
- Language:English Provider:2-Amino-5-nitrobenzophenone
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
2-Amino-5-nitrobenzophenone Usage And Synthesis
Chemical Properties
Yellow Solid
Uses
2-Amino-5-nitrobenzophenone was used in the synthesis of [5-(4-nitrophenyl)-2-furyl]acrylic acid substituted benzophenone (anti-malarial agent).
Uses
A metabolite of Nitrazepam
Synthesis Reference(s)
Synthetic Communications, 16, p. 485, 1986 DOI: 10.1080/00397918608057727
General Description
FT-IR and Raman spectra of 2-amino-5-nitrobenzophenone (ANBP) has been reported.
Synthesis
17420-30-3
873-55-2
1775-95-7
2-Cyano-4-nitroaniline (0.3 mmol), sodium benzenesulfinate (0.6 mmol), palladium acetate (10 mol%), 2,2'-bipyridine (20 mol%), p-nitrobenzenesulfonic acid (10 equiv.), tetrahydrofuran (2 mL), and water (1 mL) were sequentially added to a Schlenk tube under the protection of nitrogen atmosphere. The reaction mixture was stirred vigorously at 80 °C for 48 hours. After completion of the reaction, the mixture was poured into ethyl acetate and washed sequentially with saturated sodium bicarbonate solution (2 x 10 mL) and saturated saline (1 x 10 mL). After the aqueous layer was extracted with ethyl acetate, all organic layers were combined and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by fast column chromatography (eluent: hexane/ethyl acetate) to afford the target product 2-amino-5-nitrobenzophenone.
References
[1] Molecules, 2014, vol. 19, # 5, p. 6439 - 6449
2-Amino-5-nitrobenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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