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(R)-1-Boc-3-Aminopiperidine

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(R)-1-Boc-3-Aminopiperidine Basic information

Product Name:
(R)-1-Boc-3-Aminopiperidine
Synonyms:
  • tert-Butyl (3R)-3-aminopiperidine-1-carboxylate
  • (R)-3-Aminopiperidine, N1-BOC protected
  • (R)-1-t-Butyloxycarbonyl-3-aminopiperidine hydrochloride
  • (R)-1-Boc-3-piperidinamine, tert-Butyl (R)-3-amino-1-piperidinecarboxylate
  • (R)-3-Amino-1-N-Boc-Piperidine (R)-1-Boc-3-Aminopiperidine
  • 1-TERT-BUTYLOXYCARBONYL-3-R-AMINOPIPERIDINE HYDROCHLORIDE
  • 1-Piperidinecarboxylicacid,3-amino-,1,1-dimethylethylester,(3R)-(9CI)
  • (R)-3-AMINO-N-BOC-PIPERIDINE
CAS:
188111-79-7
MF:
C10H20N2O2
MW:
200.28
EINECS:
628-472-9
Product Categories:
  • CHIRAL CHEMICALS
  • Piperidines
  • AMINOACID
  • pharmacetical
  • Piperidine
  • Piperidine Series
Mol File:
188111-79-7.mol
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(R)-1-Boc-3-Aminopiperidine Chemical Properties

alpha 
28.5 º (c=1, DMF)
Boiling point:
277.3±33.0 °C(Predicted)
Density 
1.041±0.06 g/cm3(Predicted)
refractive index 
1.4730
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMF (Slightly), DMSO (Slightly)
pka
10.35±0.20(Predicted)
form 
Liquid
color 
Colorless to pale yellow
optical activity
[α]/D -28.5±2°, c = 1 in DMF
Water Solubility 
Immiscible with water.
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
InChIKey
AKQXKEBCONUWCL-MRVPVSSYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@@H](N)C1
CAS DataBase Reference
188111-79-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
RIDADR 
UN2735
WGK Germany 
3
10-34
HazardClass 
8
PackingGroup 
III
HS Code 
29333990

MSDS

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(R)-1-Boc-3-Aminopiperidine Usage And Synthesis

Chemical Properties

Yellow liquid

Uses

(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.

Uses

(R)-(-)-3-Amino-1-Boc-piperidine(tert-Butyl (R)-3-Aminopiperidine-1-carboxylate), is an heterocyclic building block used for the synthesis of more complex pharmaceutical compounds. It is also found to act as a γ-secretase modulators, and a potent structure for lowering Ab42 production in both in vitro and in vivo.

General Description

(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.

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