PAPA NONOATE
PAPA NONOATE Basic information
- Product Name:
- PAPA NONOATE
- Synonyms:
-
- 3-(2-HYDROXY-2-NITROSO-1-PROPYLHYDRAZINO)-1-PROPANAMINE NONOATE
- 1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-PROPYL-1-TRIAZENE
- (Z)-1-[N-(3-AMMONIOPROPYL)-N-(N-PROPYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
- (Z)-1-[N-(3-AMINOPROPYL)-N-)B-PROPYL)AMINO]DIAZIN-1-IUM-1,2-DIOLATE
- PROPYLAMINE PROPYLAMINE NONOATE
- PAPA/NO
- PAPA NONOATE
- NOC-15
- CAS:
- 146672-58-4
- MF:
- C6H16N4O2
- MW:
- 176.22
- Mol File:
- 146672-58-4.mol
More
Less
PAPA NONOATE Chemical Properties
- Boiling point:
- 277.2±42.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in Water or Ethanol.
- form
- White to off-white solid.
- pka
- 5.55±0.69(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use.
More
Less
PAPA NONOATE Usage And Synthesis
Description
PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
Uses
PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade.
Definition
ChEBI: PAPA NONOate is an alkylamine.
in vivo
PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2].
| Animal Model: | Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] |
| Dosage: | 100 μM |
| Administration: | Wounds received 100 μM PAPA NONOate in phosphate buffer |
| Result: | Increased the wound healing rate in test group. |
References
[1] L K KEEFER. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.[J]. Methods in enzymology, 1996, 268: 281-293. DOI:10.1016/s0076-6879(96)68030-6
PAPA NONOATESupplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Shanghai Macklin Biochemical Co.,Ltd.
- Tel
- 15221275939
- shenlinxing@macklin.cn
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com