1-Benzyl-3-aminopiperidine Chemical Properties

Boiling point:

82°C/0.01mmHg(lit.)

Density 

1.037±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

10.21±0.20(Predicted)

form 

powder to lump

color 

White to Almost white

CAS DataBase Reference

60407-35-4(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-37

HS Code 

29333990

1-Benzyl-3-aminopiperidine Usage And Synthesis

Chemical Properties

White powder

Synthesis

Step 2: Preparation of 3-amino-1-benzylpiperidine 2.13 g of 3-(N-acetylamino)-1-benzylpiperidine was dissolved in 10 mL of 6 N hydrochloric acid and the reaction was stirred under reflux conditions for 1 hr. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 9-10 by slow addition of 6 N aqueous ammonia solution.Subsequently, the mixture was extracted four times with chloroform (15 mL each time), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure to give 1.21 g of 3-amino-1-benzylpiperidine in 96.3% yield. The product was characterized by 1H NMR (CDCl3): δ 7.31 (m, 5H), 3.51 (s, 2H), 2.93-2.61 (m, 3H), 2.06 (t, 1H), 1.90-1.52 (m, 4H), 1.20-1.02 (m, 1H) ppm.

References

[1] Patent: EP2754655, 2014, A2. Location in patent: Paragraph 0086; 0088
[2] Patent: US2014/256711, 2014, A1. Location in patent: Paragraph 0201; 0203

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