(R)-3-Amino-1-benzylpiperidine Chemical Properties

Boiling point:

281.2±33.0 °C(Predicted)

Density 

1.037±0.06 g/cm3(Predicted)

Flash point:

113℃

storage temp. 

2-8°C(protect from light)

form 

solid

pka

10.21±0.20(Predicted)

color 

Yellow

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

168466-84-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25-36/37/38

Safety Statements 

45-37-26

HS Code 

29333990

(R)-3-Amino-1-benzylpiperidine Usage And Synthesis

Chemical Properties

White powder or yellow liquid

Uses

(R)-3-Amino-1-benzylpiperidine is used as an organic chemical synthesis intermediate.

Synthesis

Example 33: Preparation of (R)-1-benzyl-3-aminopiperidine (R)-1-benzylpiperidinamide (1.1 g) described in Example 2 was used as a starting material, which was mixed with water (5 mL), 30% aqueous sodium hydroxide (6.7 g, 10 eq.), tetrahydrofuran (THF, 10 mL), and an aqueous sodium hypochlorite solution (11.2 g, 1.5 eq.). The reaction mixture was stirred at 15°C for 1 hour, then warmed to 60°C and continued stirring for 2 hours. Upon completion of the reaction, the mixture was cooled to 20 °C and extracted three times with toluene (10 mL). After combining the organic layers, the solvent was removed by concentration under reduced pressure to afford the target product (R)-3-amino-1-benzylpiperidine as a yellow-brown oil (0.8 g, yield: 55%).

References

[1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 21

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