TAXIFOLIN 3-O-RHAMNOSIDE Chemical Properties

Melting point:

180 °C (decomp)

Boiling point:

801.1±65.0 °C(Predicted)

Density 

1.74

storage temp. 

Sealed in dry,2-8°C

solubility 

H2O: soluble1mg/mL, clear, colorless

pka

7.34±0.60(Predicted)

form 

A crystalline solid

color 

White to off-white

InChIKey

ZROGCCBNZBKLEL-MQGABXIONA-N

SMILES

O([C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)[C@H]1C(C2=C(C=C(O)C=C2O[C@@H]1C1C=CC(O)=C(O)C=1)O)=O |&1:1,4,6,8,10,12,22,r|

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

HS Code 

29389090

TAXIFOLIN 3-O-RHAMNOSIDE Usage And Synthesis

Description

Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC₅₀s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.

Uses

Astilbin displays anti-depressant activity involving monoaminergic neurotransmitters an the BDNF signal pathway. Anti-oxidant.

Definition

ChEBI: A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.

TAXIFOLIN 3-O-RHAMNOSIDE(29838-67-3)Related Product Information

• Swertiamarine
• Deacetyltaxol
• 7-EPI-10-DEACETYLTAXOL
• Cryptotanshinone
• Mogroside V
• PROCYANIDIN B2
• Dioscin
• 7-Xylosyl-10-deacetyltaxol
• 7-Epitaxol
• Cephalomannine
• Forskolin
• SCUTELLAREIN
• CASTICIN
• Hydroxysafflor yellow A
• TAXIFOLIN 3-O-RHAMNOSIDE
• PINOBANKSIN
• DIHYDROKAEMPFEROL
• (2R,3R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one