2',4',6',3,4-PENTAHYDROXYCHALCONE Chemical Properties

storage temp. 

2-8°C

InChI

InChI=1S/C15H12O6/c16-9-6-13(20)15(14(21)7-9)11(18)4-2-8-1-3-10(17)12(19)5-8/h1-7,16-17,19-21H/b4-2+

InChIKey

CRBYNQCDRNZCNX-DUXPYHPUSA-N

SMILES

C(C1=C(O)C=C(O)C=C1O)(=O)/C=C/C1=CC=C(O)C(O)=C1

LogP

2.680 (est)

2',4',6',3,4-PENTAHYDROXYCHALCONE Usage And Synthesis

Uses

Eriodictyol chalcone possesses both anti-aromatase and an anti-17β-HSD activity[1].

Definition

ChEBI: 2',3,4,4',6'-pentahydroxychalcone is a member of the class of chalcones that is chalcone substituted by hydroxy groups at positions 2', 3, 4, 4', and 6'. It is functionally related to a chalcone. It is a conjugate acid of a 2',3,4,4',6'-pentahydroxychalcone(1-).

IC 50

Aromatase

References

[1] J C Le Bail, et al. Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities. Life Sci. 2001 Jan 5;68(7):751-61. DOI:10.1016/s0024-3205(00)00974-7

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