PTEROIC ACID Chemical Properties

Melting point:

>400℃

Boiling point:

610.0±65.0 °C(Predicted)

Density 

1.69

storage temp. 

2-8°C

solubility 

Aqueous Base (Slightly), DMSO (Slightly)

pka

4.65±0.10(Predicted)

color 

Light Yellow to Brown

Safety Information

WGK Germany 

3

HS Code 

2933599590

MSDS

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PTEROIC ACID Usage And Synthesis

Uses

Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase.

Uses

Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.

Definition

ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid.

General Description

Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Enzyme inhibitor

This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.

Purification Methods

Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]

PTEROIC ACID(119-24-4)Related Product Information

• (2S)-2-[[4-[Bis[(2-aMino-4-oxo-1,4-dihydropteridin-6-yl)Methyl]aMino]benzoyl]aMino]pentanedioic Acid
• 2-Amino-7-(chloromethyl)pteridin-4(1H)-one
• 2-Amino-4-hydroxy-1H-pteridine
• Erinacine A Erinacin A
• 5-formyl-5,6,7,8-tetrahydropteroic acid
• 2-Amino-6-(chloromethyl)-4(3H)-pteridinone
• Folitixorin (Mixture of DiastereoMers)
• N-(4-aminobenzoyl)- D-Glutamic acid
• Folic acid
• 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers)
• Folic Acid Impurity C
• N-(p-Aminobenzoyl)glutamic acid
• folic acid
• 5-Methyltetrahydrofolic acid
• 10-Formylfolic Acid
• Folinic acid
• 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE
• L-Tetrahydrofolic Acid