DIETHYL OXALPROPIONATE Chemical Properties

Boiling point:

138 °C/23 mmHg (lit.)

Density 

1.073 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.432(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Hexane (Slightly), Methanol (Slightly)

form 

Oil

pka

9.30±0.46(Predicted)

color 

Clear Colourless to Pale Yellow

BRN 

1783697

CAS DataBase Reference

759-65-9(CAS DataBase Reference)

EPA Substance Registry System

Butanedioic acid, methyloxo-, diethyl ester (759-65-9)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

HS Code 

2917198090

MSDS

• Language:English Provider:SigmaAldrich

DIETHYL OXALPROPIONATE Usage And Synthesis

Uses

Reactant involved in:• ;Synthesis of anticancer and antiviral agents1• ;Oxidation by organohypervalent iodine reagent2• ;Synthesis of monomers for preparation of functional polyesters3• ;Synthesis of calpain inhibitors4• ;Preparation of human A2A receptor antagonists5• ;Structural studies of dihydropteroate synthase inhibitors6

Uses

Diethyl Oxalopropionate is a useful precursor in the synthesis of 2-Methylcitric Acid (M265080); a metabolite of Citric Acid (C521000) that can also be formed from condensation of propionoyl-CoA and oxaloacetic acid catalyzed by a citrate synthase enzyme.

Uses

Reactant involved in:

• Synthesis of anticancer and antiviral agents
• Oxidation by organohypervalent iodine reagent
• Synthesis of monomers for preparation of functional polyesters
• Synthesis of calpain inhibitors
• Preparation of human A2A receptor antagonists
• Structural studies of dihydropteroate synthase inhibitors

Definition

ChEBI: Diethyl 2-methyl-3-oxosuccinate is an alpha-ketoester, a beta-ketoester, an ethyl ester and a diester.

DIETHYL OXALPROPIONATE(759-65-9)Related Product Information

• Diethyl oxalacetate
• Diethyl succinate
• Methyl pyruvate
• DIETHYL OXALPROPIONATE
• Oxobutanedioic acid
• Methyl 2-oxoacetate
• MONO-METHYL SUCCINATE
• Ethyl acetoacetate
• Ethyl 3-methyl-2-oxobutyrate
• Methyl 4-methoxybutanoate
• Ethyl 3-oxobutanoate sodium salt
• Ethyl 2-methylacetoacetate
• Pyruvic acid
• MONO-ETHYL SUCCINATE
• 3-CHLORO-2-METHYLBENZYLAMINE
• Ethyl pyruvate
• ETHYL 4-METHOXY-3-OXO-BUTANOATE
• Methyl 4-methoxyacetoacetate