Methyl 4-methoxyacetoacetate Chemical Properties

Melting point:

-80℃

Boiling point:

89 °C/8.5 mmHg (lit.)

Density 

1.129 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.431(lit.)

Flash point:

193 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

9.88±0.46(Predicted)

color 

Colorless to Light yellow to Light orange

Specific Gravity

1.129

BRN 

1761215

InChIKey

QGBPKJFJAVDUNC-UHFFFAOYSA-N

LogP

0.340 (est)

CAS DataBase Reference

41051-15-4(CAS DataBase Reference)

NIST Chemistry Reference

Methyl 4-methoxyacetoacetate(41051-15-4)

EPA Substance Registry System

Methyl 4-methoxyacetoacetate (41051-15-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10

HS Code 

29189900

MSDS

• Language:English Provider:Methyl 4-methoxy-3-oxo-butanoate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

Methyl 4-methoxyacetoacetate Usage And Synthesis

Chemical Properties

colorless to yellow liquid

Uses

Methyl 4-Methoxyacetoacetate is a reactant in the formation of an abiotic poorphyrinogen in aqueous solution.

Uses

Methyl 4-methoxyacetoacetate has been used in generation of a small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and (thio)ureas.

Preparation

The preparation method of a 4-methoxyl group methyl acetoacetate: add solvents tetrahydrofurane in a kettle. and pass into rare gas element, the temperature in the kettle arranging reactor is 15-25℃, industrial sodium hydride and metal alkaline compound is added under whipped state, add solvents tetrahydrofurane again, the mixed solution reaction 4-6h of methyl alcohol and 4-chloro methyl acetoacetate is dripped in less than 20℃, then be warming up to 20-25℃ and continue reaction 4-15h, TLC detection reaction is complete, reduce system temperature to 6-10℃, add the hydrochloric acid soln regulation system pH=5-7 that volumetric molar concentration is 2mol/L, stratification, after separatory, upper strata is concentrated is spin-dried for removing solvents tetrahydrofurane, then colorless product 4-methoxyl group methyl acetoacetate is obtained by wiped film molecular distillation.

Methyl 4-methoxyacetoacetate(41051-15-4)Related Product Information

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