Basic information Safety Supplier Related

HOOCCH2CH2-PEG16-CH2CH2COOH

Basic information Safety Supplier Related

HOOCCH2CH2-PEG16-CH2CH2COOH Basic information

Product Name:
HOOCCH2CH2-PEG16-CH2CH2COOH
Synonyms:
  • HOOCCH2CH2-PEG16-CH2CH2COOH
  • 4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52-Heptadecaoxapentapentacontanedioic acid
  • Di-Acid-PEG17
  • HOOCCH2CH2O-PEG16-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52-Heptadecaoxapentapentacontanedioic acid
CAS:
2226897-74-9
MF:
C38H74O21
MW:
866.98
Mol File:
2226897-74-9.mol
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HOOCCH2CH2-PEG16-CH2CH2COOH Usage And Synthesis

Biological Activity

Bis-PEG17-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HOOCCH2CH2-PEG16-CH2CH2COOHSupplier

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