HOOCCH2CH2-PEG16-CH2CH2COOH Chemical Properties

form 

Solid

color 

Off-white to light yellow

HOOCCH2CH2-PEG16-CH2CH2COOH Usage And Synthesis

Biological Activity

Bis-PEG17-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HOOCCH2CH2-PEG16-CH2CH2COOH(2226897-74-9)Related Product Information

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• INDEX NAME NOT YET ASSIGNED
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