2-ATRACTYLENOLIDE
2-ATRACTYLENOLIDE Basic information
- Product Name:
- 2-ATRACTYLENOLIDE
- Synonyms:
-
- ASTEROLIDE
- 2-ATRACTYLENOLIDE
- Atractylenolide II (Asterolide)
- (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-Octahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
- Atractylenolide Ⅱ
- Atractylenolide II, BR
- Atracylenolide II
- Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
- CAS:
- 73069-14-4
- MF:
- C15H20O2
- MW:
- 232.32
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 73069-14-4.mol
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2-ATRACTYLENOLIDE Chemical Properties
- Melting point:
- 150-152 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 378.0±41.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in chloroform
- form
- powder
- color
- White
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2-ATRACTYLENOLIDE Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Atractylodes macrocephala Koidz.
Uses
food and beverages
Definition
ChEBI: Atractylenolide II is a sesquiterpene lactone.
in vivo
Atractylenolide II (12.5-25 mg/kg; Oral gavage; 14 days) has antitumor effect in a B16 xenograft mouse model[3].
Atractylenolide II (10-60 mg/kg/d; Intraperitoneal injection; 8 weeks) improves myocardial fibrosis and oxidative stress in spontaneously hypertensive rats[4].
| Animal Model: | C57/BL6 mice with a B16 xenograft model[3] |
| Dosage: | 12.5 and 25 mg/kg |
| Administration: | Oral gavage (i.g.); 14 days |
| Result: | Significantly inhibited tumor growth. Inhibited the activation/phosphorylation of STAT3 and Src. |
| Animal Model: | Spontaneous hypertension rats[4] |
| Dosage: | 10, 30 and 60 mg/kg/d |
| Administration: | Intraperitoneal injection (i.p.); 8 weeks |
| Result: | Improved the body weight of spontaneous hypertension rats and enhanced myocardial function in a dose-dependent manner. Effectively reduced cardiomyocyte apoptosis. Inhibited the Collagen I, α-SMA, Fibronectin and Vimentin mRNA and protein expression levels. Ameliorated oxidative stress by improving the activities of SOD and GSH-PX and lowering the contents of H2O2 and MDA, which reached about 80%. |
IC 50
p-STAT3
2-ATRACTYLENOLIDESupplier
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