Urocortin II (mouse) CAS#: 330648-32-3

Urocortin II (mouse) Basic information

Product Name:

Urocortin II (mouse)

Synonyms:

H-VAL-ILE-LEU-SER-LEU-ASP-VAL-PRO-ILE-GLY-LEU-LEU-ARG-ILE-LEU-LEU-GLU-GLN-ALA-ARG-TYR-LYS-ALA-ALA-ARG-ASN-GLN-ALA-ALA-THR-ASN-ALA-GLN-ILE-LEU-ALA-HIS-VAL-NH2 TRIFLUOROACETATE
UCN II (MOUSE) TRIFLUOROACETATE
UROCORTIN II (MOUSE) TRIFLUOROACETATE
UROCORTIN II (MOUSE)

CAS:

330648-32-3

MW:

0

Mol File:

Mol File

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Urocortin II (mouse) Chemical Properties

storage temp.: -20°C
form: Solid
color: White to off-white
biological source: mouse
Sequence: Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2

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Urocortin II (mouse) Usage And Synthesis

Uses

Mouse urocortin II can be used for immunohistochemistry.

Biochem/physiol Actions

Urocortin II is a CRF-related neuropeptide having high affinity for CRF2 receptor. It stimulates protein kinase A through CRF2 receptor and increases the contractility in rabbit ventricular myocytes. It also facilitates pro-inflammatory effects in human intestinal cells through corticotropin-releasing hormone receptor 2α.

in vivo

Urocortin II, mouse (1-10 μg; icv and i.v.; Adult male Sprague-Dawley rats) induces the expression of Fos^[2].
Urocortin II, mouse (1 μg; icv; Adult male Sprague-Dawley rats) is involved in central autonomic nervous system and appetite control^[2].

Animal Model:	Adult male Sprague-Dawley rats (250-300 g)^[2]
Dosage:	1, 5, and 10 μg
Administration:	Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration
Result:	Induced Fos expression in a dose-dependent manner.

Animal Model:	Adult male Sprague-Dawley rats (250-300 g)^[2]
Dosage:	1 μg
Administration:	Intracerebroventrical injection
Result:	Reduced food intake over the 12-h interval.

IC 50

CRFR2: 0.66 nM (Ki); CRFR1: ﹥100 nM (Ki)

Urocortin II (mouse) Supplier

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Email: info@cellmano.com

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com

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