sophoflavescenol Chemical Properties

Melting point:

273-275 °C

Boiling point:

631.8±55.0 °C(Predicted)

Density 

1.359±0.06 g/cm3(Predicted)

storage temp. 

4°C, away from moisture and light

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

7.03±0.40(Predicted)

color 

Yellow

sophoflavescenol Usage And Synthesis

Uses

Sophoflavescenol is a potential cytotoxic agent against lung cancer A549 cells and colon cancer HCT116 cells.

Synthesis

7,8-(2,2-Dimethyl-2H-pyran)-5,4-dihydroxyflavonol (Sophorol, 12):(CH3)2SO4 (10.53 mmol, 1.0 mL) was added dropwise to a stirred solution of 11 (500 mg, 1.02 mmol) in NaOH (5% aqueous solution; 15 mL). The mixture was stirred at room temperature and maintained at pH 9-10 for 5 hours. Thereafter, the reaction mixture was adjusted to pH 6 using HCl (2% aqueous solution) and then extracted with the mixture. Water anhydrous Na2SO4 was dried free and the solvent was evaporated. The solid residue was recrystallized EtOAc/petroleum ether from it to give locust flavanol (181 mg, 96%) as yellow needles with a melting point melting point 272-274??C.

in vivo

target

Caspase | ROS | NF-kB | NO | BACE | PDE

IC 50

BACE1; AChE; BChE; PDE5

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