Biotin-PEG3-SS-azide
Biotin-PEG3-SS-azide Basic information
- Product Name:
- Biotin-PEG3-SS-azide
- Synonyms:
-
- Biotin-PEG3-SS-azide
- 12,15,18-Trioxa-4,5-dithia-8,21-diazahexacosanamide, N-(3-azidopropyl)-26-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,22-dioxo-
- CAS:
- 2866429-93-6
- MF:
- C27H48N8O7S3
- MW:
- 692.92
- Mol File:
- 2866429-93-6.mol
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Biotin-PEG3-SS-azide Chemical Properties
- form
- Oil
- color
- White to light yellow
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Biotin-PEG3-SS-azide Usage And Synthesis
Uses
Biotin-PEG3-amido-SS-amido-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG3-amido-SS-amido-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Biotin-PEG3-SS-azideSupplier
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TargetMol Chemicals Inc.
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