DBCO-S-S-PEG3-Biotin
DBCO-S-S-PEG3-Biotin Basic information
- Product Name:
- DBCO-S-S-PEG3-Biotin
- Synonyms:
-
- DBCO-S-S-PEG3-Biotin
- CAS_1430408-09-5
- Biotin-PEG3-SS-DBCO
- Dibenzocyclooctyne-S-S-PEG3-Biotin
- N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
- inhibit,PROTAC Linkers,DBCO-S-S-PEG-3-biotin,Inhibitor,DBCOSSPEG3biotin,DBCO S S PEG3 biotin
- Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[25-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-7,21-dioxo-11,14,17-trioxa-3,4-dithia-8,20-diazapentacos-1-yl]-γ-oxo-
- Disulfide Biotin DBCO (CCT-A112)
- CAS:
- 1430408-09-5
- MF:
- C42H56N6O8S3
- MW:
- 869.12
- Mol File:
- 1430408-09-5.mol
DBCO-S-S-PEG3-Biotin Chemical Properties
- Boiling point:
- 1194.2±65.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- solubility
- DMSO : 100 mg/mL (115.06 mM; Need ultrasonic)
- form
- Oil
- pka
- 13.90±0.40(Predicted)
- color
- Light yellow to brown
DBCO-S-S-PEG3-Biotin Usage And Synthesis
Description
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.
Uses
DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-S-S-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DBCO-S-S-PEG3-BiotinSupplier
- Tel
- 03-36680489
- Sales-JP@TCIchemicals.com
- Tel
- 320-37350700
- sales@tcieurope.eu
- Tel
- 800-4238616
- sales@tciamerica.com
- Tel
- 15221275939
- shenlinxing@macklin.cn
- Tel
- 021-58088081 Q2635253576
- hailey@shsendpharm.com
DBCO-S-S-PEG3-Biotin(1430408-09-5)Related Product Information
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- DBCO-PEG3-NH2
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- N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE
- Sulfo-NHS-Biotin
- BIOTIN-NHS
- Biotin-PEG3-oxyamine
- BIOTINAMIDOCAPROYL HYDRAZIDE
- Biotin-PEG3-propionic hydrazide
- BIOTIN-X-NHS, WATER-SOLUBLE, CLEAVABLE
- BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
- BIOTIN HYDRAZIDE
- N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE
- Biotin-PEG3-SH
- Biotin-peg3-alcohol