BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER Chemical Properties

Melting point:

129-131°C

Density 

1.43

storage temp. 

−20°C

solubility 

DMF: 50 mg/mL

form 

powder

pka

13.90±0.40(Predicted)

Safety Information

Hazard Codes 

T

Risk Statements 

61

Safety Statements 

53-23-36/37/39-45

WGK Germany 

1

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER Usage And Synthesis

Description

Biotin-bisamido-SS-NHS is a cleavable reagent which can efficiently introduce a biotin moiety to amine-containing biomolecules. The cross-bridge and extended spacer arm are helpful in minimizing steric hindrance involved with the binding to avidin or streptavidin probes. This biotin compound is membrane-permeable and useful for intracellular labeling. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.

Uses

NHS SS Biotin is a amine reactive biotinylation reagent that labels antibodies and other proteins and molecules that contain primary amines. NHS SS Biotin reacts efficiently with pirmary amino groups in alkaline buffers to form stable amide bonds. The disulfide bond in the spacer arm of NHS SS Biotin is also cleavable using reducing agents such as TCEP and DTT.

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