BIOTINAMIDOCAPROYL HYDRAZIDE Chemical Properties

Melting point:

195-196°C

Boiling point:

777.0±55.0 °C(Predicted)

Density 

1.188±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 25 mg/mL

form 

powder

pka

13.26±0.35(Predicted)

color 

White to Almost white

InChIKey

IJJWOSAXNHWBPR-HUBLWGQQSA-N

CAS DataBase Reference

109276-34-8(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

-

F 

10-21

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

BIOTINAMIDOCAPROYL HYDRAZIDE Usage And Synthesis

Description

This is a hydrazide-activated biotinylation reagent used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The extended spacer arm helps to minimize steric hindrance.

Chemical Properties

mp 195°C

Uses

Biotinylation reagent with aminocaproic spacer for aldehyde groups (e.g., periodate-oxidized sugars) and carboxylic acids. Typically used for coupling to glycoproteins through the carbohydrate by hydrazone bond formation.

Purification Methods

Suspend the hydrazide in ice-water (100mg/mL), stand overnight at 4o, filter and dry the solid in a vacuum. Recrystallise it from isoPrOH. RF is 0.26 on SiO2 plate using CHCl3/MeOH (7:3) as eluent. [O'Shannessy et al. Anal Biochem 163 204 1987.]

BIOTINAMIDOCAPROYL HYDRAZIDE(109276-34-8)Related Product Information

• D-Biotin
• N-Biotinyl-N'-(iodoacetyl)-1,6-hexanediaMine
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• Succinimidyl 6-(biotinamido)hexanoate
• Sulfo-NHS-SS-Biotin
• N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE
• Sulfo-NHS-Biotin
• BIOTIN-NHS
• Biotin-PEG3-oxyamine
• Biotin-PEG3-propionic hydrazide
• BIOTIN-X-NHS, WATER-SOLUBLE, CLEAVABLE
• BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER
• DBCO-S-S-PEG3-Biotin
• N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE
• BIOTIN HYDRAZIDE
• 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, (3aS,4S,6aR)-
• Biotin-LC-PEG4-NHS ester
• BIOTIN-XX-NHS