Glyoxylic acid
Glyoxylic acid Basic information
- Product Name:
- Glyoxylic acid
- Synonyms:
-
- alpha-ketoaceticacid
- ACETIC ACID, OXO-
- GA
- GLYOXALIC ACID
- GLYOXYLIC ACID
- oxo-aceticaci
- oxo-acetic acid
- Glyoxylic acid, 50 wt.% solution in H2O
- CAS:
- 298-12-4
- MF:
- C2H2O3
- MW:
- 74.04
- EINECS:
- 206-058-5
- Product Categories:
-
- Pharmaceutical Intermediates
- Chemical raw materials
- intermediates and semifinished medicines
- bc0001
- 298-12-4
- Mol File:
- 298-12-4.mol
Glyoxylic acid Chemical Properties
- Melting point:
- -93°C
- Boiling point:
- 111°C
- Density
- 1.33 g/mL at 20 °C
- vapor pressure
- 14hPa at 19.85℃
- refractive index
- n20/D 1.414
- Flash point:
- 111°C
- storage temp.
- Store below +30°C.
- solubility
- Miscible with ethanol. Slightly miscible with ether and benzene. Immiscible with esters.
- pka
- 3.18(at 25℃)
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- Water Solubility
- miscible
- Merck
- 14,4511
- BRN
- 741891
- InChIKey
- HHLFWLYXYJOTON-UHFFFAOYSA-N
- LogP
- -0.930 (est)
- CAS DataBase Reference
- 298-12-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, oxo-(298-12-4)
- EPA Substance Registry System
- Acetic acid, 2-oxo- (298-12-4)
Safety Information
- Hazard Codes
- C,Xi
- Risk Statements
- 34-43-41
- Safety Statements
- 26-36/37/39-45-37/39-24
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 1
- RTECS
- MD4550000
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29183000
- Hazardous Substances Data
- 298-12-4(Hazardous Substances Data)
- Toxicity
- rat,LDLo,intramuscular,250mg/kg (250mg/kg),Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 36, Pg. 1937, 1960.
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Glyoxylic acid Usage And Synthesis
Chemical Properties
Colorless clear liquid.
Uses
Glyoxalic acid can be used in the synthesis of a variety of reactions.
Glyoxylic acid is used in Hopkins Cole reaction, which is used in the detection of tryptophan in proteins.
It reacts with phenol to get 4-hydroxymandelic acid, which on further reaction with ammonia gives hydroxyphenylglycine, as a precursor to the drug amoxicillin.
It is also used as a starting material for the preparation of 4-hydroxyphenylacetic acid, which is used to get atenolol.
Definition
ChEBI: A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.
General Description
Supplied as a 50% aqueous solution.
Health Hazard
Contact will cause severe eye and skin burns. Vapor exposure may cause eye and skin irritation.
Flammability and Explosibility
Non flammable
Biological Activity
nsc 27785 is an organic compound that is both an aldehyde and a carboxylic acid.
Synthesis
Add to 3500ml reactor equipped with reflux condenser, stirrer and thermometer300ml (3.55mol) of 50% glyoxal solution, stir and cool, control the temperature to 7±2,Slowly drip 300ml (3.55mol) of 35% hydrogen peroxide solution at the same time within 3 hours,280ml (0.355mol) of 17% ferrous sulfate solution and 120ml (0.75mol) of 15% aqueous ammonia solution, keep at 8±2, react for 3 hours, and let stand overnight, The reaction liquid was filtered to remove the solid by-products, and 350ml of water-carrying toluene was added to the reaction mother liquid.Heat to reflux, remove water, and distill toluene with water-carrying agent to obtain oxidation product.Add 120ml of concentrated sulfuric acid and 700ml of absolute ethanol to the oxidation products.Esterification reaction at 140°C for 3 hours, then distillation under reduced pressure, at 0.02Mpa,The esterification product was collected at 185°C.Add 120ml of 18% sulfuric acid to the esterified product and heat under stirring.The hydrolysis reaction is carried out at 95-98 for 2 hours; the hydrolysis liquid is cooled to room temperature,The precipitated white solid product was filtered, washed 4 times with 120ml of toluene each time, and dried.Obtain 180 g of the target product glyoxylic acid with a purity of 99.5% (HPLC) and a yield of 88%.Melting point is 98.1-98.6.
Glyoxylic acid Preparation Products And Raw materials
Preparation Products
Raw materials
Glyoxylic acidSupplier
- Tel
- 0713-5067896 13636091935
- fanguoxian1958@163.com
- Tel
- 0317-5304268 13582748294
- info@goldlionchem.com
- Tel
- 400-1166-196 13458535857
- cdhxsj@163.com
- Tel
- 0751-2886766 13927870850
- 3001267247@qq.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Glyoxylic acid(298-12-4)Related Product Information
- METHYL OXALYL CHLORIDE
- MESOXALIC ACID MONOHYDRATE DISODIUM SALT
- Glyoxylic acid, chloro-, ethyl ester
- Ethyl 2-(Chlorosulfonyl)acetate
- (1R)-(-)-Menthyl glyoxylate hydrate
- KETOMALONIC ACID
- Acetic anhydride
- Chloroacetic acid
- sodium phenylglyoxylate
- Ascoric Acid
- Methyl 2-oxoacetate
- Folic acid
- Glycine
- Calcium alpha-ketovaline
- Ethyl acetate
- 2-KETO-D-GLUCONIC ACID HEMICALCIUM SALT
- phosphoric acid
- Citric acid
- Glyoxylate